Results 71 to 80 of about 758 (213)

Regression discontinuity design for the study of health effects of exposures acting early in life

Frontiers in Public Health
Regression discontinuity design (RDD) is a quasi-experimental approach to study the causal effect of an exposure on later outcomes by exploiting the discontinuity in the exposure probability at an assignment variable cut-off.
Maja Popovic, Daniela Zugna, Kate Tilling, Kate Tilling, Lorenzo Richiardi   +4 more
doaj   +1 more source

Application of Regression Discontinuity in Investigating the Effectiveness of Lidcombe Program on Decreasing the Severity of Stuttering in Primary School Children: A Single-Subject Research

تحقیقات نظام سلامت, 2021
Background: In single-subject research, there is an autocorrelation between observations, that violates the assumption of observational independence. The regression discontinuity considers the correlation between observations over time and in different ...
Ali Halabisaz-Esfahani, Akbar Hassanzadeh, Behzad Mahaki, Atefeh Mirmoeini, Zahra Heidari   +4 more
doaj  

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Does far-right legislative entry affect minority candidate diversity?

Political Science Research and Methods
Using a regression discontinuity design, we examine the causal impact of far-right parties’ first-time entry into Swedish municipal politics on the inclusion of candidates from groups frequently targeted by their rhetoric, namely immigrants and sexual ...
Michal Grahn, Stuart J. Turnbull-Dugarte
doaj   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Effects of Nutrition Promotion on Child Growth in El Alto, Bolivia: Results from a Geographical Discontinuity Design

Economía, 2016
Interventions that offer growth monitoring and nutrition counseling services to families with young children are one of the cornerstones of nutrition policy in developing countries.
Gaston Gertner, Julia Johannsen, Sebastian Martinez   +2 more
doaj   +1 more source

History matters: development and institutional persistence of the Habsburg Military Frontier in Croatia

Public Sector Economics, 2020
In this paper we explore the effect of the long-gone Habsburg Military Frontier on modern institutions in Croatia. We use the Life in Transition Survey and geographic regression discontinuity design to identify the causal mechanism between historical ...
Marina Tkalec
doaj   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Regression Discontinuity Design with Many Thresholds [PDF]

SSRN Electronic Journal, 2015
Numerous empirical studies employ regression discontinuity designs with multiple cutoffs and heterogeneous treatments. A common practice is to normalize all the cutoffs to zero and estimate one effect. This procedure identifies the average treatment effect (ATE) on the observed distribution of individuals local to existing cutoffs. However, researchers
openaire   +4 more sources

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source