Results 121 to 130 of about 410,064 (354)

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Political Parties and the Tax Level in the American States: A Regression Discontinuity Design [PDF]

With a regression discontinuity design I show that the partisan identity of the majority in the state House of Representatives has no causal effect on the tax level. This result goes against recent findings in the political economy literature.
Leandro M. de Magalhães
core  

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source

Sequential methods for design-adaptive estimation of discontinuities in regression curves and surfaces [PDF]

, 2003
Peter Hall, Ilya Molchanov
openalex   +1 more source

Evaluating the Effect of an Antidiscrimination Law Using a Regression-Discontinuity Design [PDF]

The regression discontinuity (RD) data design is a quasi-experimental design with the defining characteristic that the probability of receiving treatment changes discontinuously as a function of one or more individual characteristics.
Jinyong Hahn, Petra Todd, Wilbert Van der Klaauw   +2 more
core  

Tumor‐Tissue Boundaries as Instructive Interfaces in Breast Cancer Cell Invasion

Advanced Science, EarlyView.
Tumor‐tissue boundaries reprogram metastatic breast cancer cells, enhancing invasiveness through an instructive, not permissive, mechanism. Using a 3D collagen I‐based tumor‐tissue interface model, single‐cell analysis, and simulations, this study shows that all cells can transmigrate without selective filtering, highlighting a targetable process in ...
Cornelia Clemens, Thomas Zerjatke, Andrine Frank, Hannah Trampert, Nataliia Kotsiuba, Ingmar Glauche, Tilo Pompe   +6 more
wiley   +1 more source

Political Dynasties and Local Spending in Indonesia

Jurnal Ekonomi Pembangunan
Does political dynasty affect local spending in Indonesia?  Only a few articles have taken up the political economy issues in Indonesia This study provides empirical analysis that focuses on explaining the effect of the political competition through ...
Dwi Putri Larasati, Jahen Fachrul Rezki
doaj   +1 more source

Using Regression Discontinuity Design to Identify the Effect of Zoning [PDF]

We test the effect of minimum lot zoning on rural-to-urban land use conversion using Regression Discontinuity Design (RDD), a technique that exploits natural discontinuities in the data to identify causal effects.
Carrion-Flores, Carmen E., Irwin, Elena G.   +1 more
core   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

The impact of deep brain stimulation payment adjustments on healthcare utilization in Shanghai, China: a regression discontinuity analysis of health insurance claims

BMC Health Services Research
Background and objectives Recently, the financial burden on medical insurance funds has increased rapidly. The policy effects of paying for innovation await scientific measurement.
Qian Xing, Tianchi Chen, Hongfei Hu, Da He, Wei Wang, Yue Yin, Haiyin Wang   +6 more
doaj   +1 more source