Results 71 to 80 of about 354,947 (289)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Ridge regression estimator: combining unbiased and ordinary ridge regression methods of estimation [PDF]
Surveys in Mathematics and its Applications, 2009 Statistical literature has several methods for coping with multicollinearity. This paper introduces a new shrinkage estimator, called modified unbiased ridge (MUR).
Sharad Damodar Gore, Feras Sh. M. Batah
doaj
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The Hilbert Kernel Regression Estimate
Journal of Multivariate Analysis, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Devroye, Luc +2 more
openaire +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
New ridge parameter estimators for the quasi-Poisson ridge regression model
Scientific ReportsThe quasi-Poisson regression model is used for count data and is preferred over the Poisson regression model in the case of over-dispersed count data.
Aamir Shahzad +3 more
doaj +1 more source
Some one and two parameter estimators for the multicollinear gaussian linear regression model: simulations and applications [PDF]
Surveys in Mathematics and its Applications, 2023 The ordinary least square estimator is inefficient when there exists multicollinearity among regressors in linear regression model. There are many methods available in literature to solve the multicollinearity problem. In this study, we consider some one
Md Ariful Hoque , B. M. Golam Kibria
doaj
, 2007 We consider the linear regression problem of estimating an unknown, deterministic parameter vector based on measurements corrupted by colored Gaussian noise. We present and analyze blind minimax estimators (BMEs), which consist of a bounded parameter set
Ben-Haim, Zvika, Eldar, Yonina C.
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source