Mesenchymal Stem Cell Therapy Facilitates Donor Lung Preservation by Reducing Oxidative Damage during Ischemia [PDF]
Stem Cells International, 2019 Lung transplantation is a lifesaving therapy for people living with severe, life-threatening lung disease. The high mortality rate among patients awaiting transplantation is mainly due to the low percentage of lungs that are deemed acceptable for ...
Natalia Pacienza +7 more
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AAV-HDV: An Attractive Platform for the In Vivo Study of HDV Biology and the Mechanism of Disease Pathogenesis [PDF]
Viruses, 2021 Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, but little is known about the molecular mechanisms involved. We have recently developed an HDV mouse model based on the delivery of HDV replication-competent genomes ...
Sheila Maestro +8 more
doaj +2 more sources
Editorial for Special Issue “Yeasts Biochemistry and Biotechnology” [PDF]
MicroorganismsYeasts, both Saccharomyces and non-conventional strains, are currently the focus of active research due to their impressive applications in biotechnological bioprocesses, such as being hosts to produce recombinant proteins or main actors of the ...
María-Isabel González-Siso +1 more
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Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions [PDF]
Technology in Cancer Research & Treatment, 2020 Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with ...
Mujib Ullah MD, PhD +2 more
doaj +2 more sources
A dataset of proteins associated with Trypanosoma cruzi LYT1 mRNAs [PDF]
Data in Brief, 2022 Post-transcriptional gene regulation in Trypanosoma cruzi, the etiological agent of Chagas disease, plays a critical role in ensuring that the parasite successfully completes its life cycle in both of its obligate hosts: insect vector and mammals.
Elizabeth Ruiz Márvez +3 more
doaj +2 more sources
Perinatal derivatives: How to best validate their immunomodulatory functions [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Perinatal tissues, mainly the placenta and umbilical cord, contain a variety of different somatic stem and progenitor cell types, including those of the hematopoietic system, multipotent mesenchymal stromal cells (MSCs), epithelial cells and amnion ...
Andrea Papait +19 more
doaj +2 more sources
The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells [PDF]
BMC Research Notes, 2019 Objective Redox homeostasis maintenance is essential to bring about cellular functions. Particularly, embryonic stem cells (ESCs) have high fidelity mechanisms for DNA repair, high activity of different antioxidant enzymes and low levels of oxidative ...
Claudia Solari +9 more
doaj +2 more sources
Heme oxygenase up-regulation under ultraviolet-B radiation is not epigenetically restricted and involves specific stress-related transcriptions factors [PDF]
Redox Biology, 2017 Heme oxygenase-1 (HO-1) plays a protective role against oxidative stress in plants. The mechanisms regulating its expression, however, remain unclear. Here we studied the methylation state of a GC rich HO-1 promoter region and the expression of several ...
Diego Santa-Cruz +5 more
doaj +2 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Cancer is the second leading cause of death worldwide, with 10.0 million cancer deaths in 2020. Despite advances in targeted therapies, some pharmacological drawbacks associated with anticancer chemo and immunotherapeutic agents include high toxicities ...
María Cecilia Sanmartin +5 more
doaj +1 more source
CRISPR-Cas, el editor de genes
Revista del Hospital Italiano de Buenos Aires, 2021 El término CRISPR, por su acrónimo en inglés refiere a Clustered Regularly Interspaced Short Palindromic Repeats, es decir, repeticiones palindrómicas cortas, agrupadas y regularmente esparcidas, por sus características en el genoma, pertenece ...
Daiana M. Ibáñez Alegre +2 more
doaj +1 more source