Results 61 to 70 of about 244,712 (267)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Multi-Channel Multi-Scale Convolution Attention Variational Autoencoder (MCA-VAE): An Interpretable Anomaly Detection Algorithm Based on Variational Autoencoder

Sensors
With the rapid development of industry, the risks factories face are increasing. Therefore, the anomaly detection algorithms deployed in factories need to have high accuracy, and they need to be able to promptly discover and locate the specific equipment
Jingwen Liu, Yuchen Huang, Dizhi Wu, Yuchen Yang, Yanru Chen, Liangyin Chen, Yuanyuan Zhang   +6 more
doaj   +1 more source

The Non-Regular CEO Problem

, 2015
We consider the CEO problem for non-regular source distributions (such as uniform or truncated Gaussian). A group of agents observe independently corrupted versions of data and transmit coded versions over rate-limited links to a CEO.
Varshney, Lav R., Vempaty, Aditya
core   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

Reliability Analysis of CVT Online Monitoring Device Based on Bayesian Network

Energies
To address the challenges of equipment reliability assessment in the context of intelligent power systems, especially the shortcomings of traditional methods in dealing with multi-factor coupling and uncertain fault inference of CVT (capacitive voltage ...
Xu Chen, Haomiao Zhang, Chao Zhang, Yinzhe Xu, Yu Yan, Yuntao Zhao, Xuhui Chen, Rui Ren   +7 more
doaj   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Estimation of bivariate excess probabilities for elliptical models

, 2006
Let $(X,Y)$ be a random vector whose conditional excess probability $\theta(x,y):=P(Y\leq y | X>x)$ is of interest. Estimating this kind of probability is a delicate problem as soon as $x$ tends to be large, since the conditioning event becomes an ...
Abdous, Belkacem, Fougères, Anne-Laure, Ghoudi, Kilani, Soulier, Philippe   +3 more
core   +6 more sources

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Perfect Regular Equilibrium [PDF]

We propose a revised version of the perfect Bayesian equilibrium in general multi-period games with observed actions. In finite games, perfect Bayesian equilibria are weakly consistent and subgame perfect Nash equilibria.
hanjoon michael, jung/j
core   +1 more source