Results 111 to 120 of about 7,473,929 (357)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimization and Security Analysis of Interconnected Security Control Based on Semantic of Process Communication

天地一体化信息网络, 2021
Facing the demand of multi-domain security control in the integrated network of air and ground, to solve the problem that singleprocess regular matching restricts the performance of interconnected security gateway, the method of high-performance ...
Bo LU, Yueming LU
doaj   +2 more sources

Improved space protocol identification algorithm

Tongxin xuebao, 2012
An improved boyer-moore (BM) algorithm for space protocol identification was proposed.First,a space data preprocessing technique based on bit distance was used to increase the size of data set.A decimal jumping technique was introduced to enhance the ...
Tian-ming ZHENG, Tao WANG, Shi-ze GUO, Hua LI, Xin-jie ZHAO   +4 more
doaj  

Regularity preserving modifications of regular expressions

Information and Control, 1963
This paper is concerned with the problem of determining whether a set of sequences R\t', obtained by some given rule from a regular set of sequences R, is again a regular set. A number of such problems are solved in this paper and a basic technique is used which is easy to apply to problems of this type.
Stearns, R.E., Hartmanis, J.
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

NUWT: JAWI-SPECIFIC BUCKWALTER CORPUS FOR MALAY WORD TOKENIZATION

Journal of ICT, 2016
This paper describes the design and creation of a monolingual parallel corpus for the Malay language written in Jawi. This paper proposes a new corpus called the National University of Malaysia Word Tokenization (NUWT) corpora To the best of our ...
Juhaida Abu Bakar, Khairuddin Omar, Mohammad Faidzul Nasrudin, Mohd Zamri Murah   +3 more
doaj  

Automated extraction of ejection fraction for quality measurement using regular expressions in Unstructured Information Management Architecture (UIMA) for heart failure [PDF]

, 2012
Jennifer H. Garvin, Scott L. DuVall, Brett R. South, Bruce E. Bray, Dan Bolton, Julia Heavirland, Steve Pickard, Paul A. Heidenreich, Shuying Shen, Charlene Weir, Matthew H. Samore, Mary K. Goldstein   +11 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source