Results 141 to 150 of about 7,225,806 (376)
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Covariance and PCA for Categorical Variables
, 2007 Covariances from categorical variables are defined using a regular simplex expression for categories. The method follows the variance definition by Gini, and it gives the covariance as a solution of simultaneous equations.
Niitsuma, Hirotaka, Okada, Takashi
core +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Regular expression based pattern extraction from a cell - Specific gene expression data
Informatics in Medicine Unlocked, 2019 Cancer cells are formed when active genes stop functioning properly. Timely activation of a gene is governed through the combined effort of multiple Transcription Factors (TFs). TFs are proteins that bind on DNA in a sequence-specific manner.
Suja Subramanian, Tessamma Thomas
doaj
Highly Parallel Regular Expression Matching Using a Real Processing-in-Memory System
IEEE AccessProcessing-in-Memory (PIM) is an emerging computing paradigm exploiting a cutting-edge memory device (PIM device) that integrates hundreds to thousands of processing units with the memory modules. A data-intensive application running in a host system can
Jeonghyeon Joo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
A data matching algorithm based on instruction pipeline
Dianzi Jishu YingyongThe data matching technology based on regular expressions has significant application value in basic data governance and cleaning. However, in the data processing process of high-performance computing, the low performance of algorithm matching cannot ...
Yang Jiajia +5 more
doaj +1 more source