Results 191 to 200 of about 413,827 (305)

Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction. [PDF]

Circ Res
Huang K, Huang Y, Zhang Y, Zhang Y, Hatch NW, Freed JK, Cai H.   +6 more
europepmc   +1 more source

High-Performance Regular Expression Matching with Parabix and LLVM [PDF]

, 2014
Denis, Dale Lamont
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer. [PDF]

Mol Cell
Hubbi ME, Wang CL, Suhail Y, Almasri NL, Xie J, Hollander EE, Kshitiz, Muir A, Stanger BZ, Dang CV.   +9 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

ceQTL: a co-expression QTL model to detect a variant that affects transcription factor binding and its target regulation. [PDF]

Brief Bioinform
Wang P, Chen Y, Liu Y, Liu L, Yang P, Wang J, Sun Z.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Regular parental pre-mating exercise reduces offspring white adiposity and is associated with hypothalamic neurodevelopmental changes during lactation. [PDF]

Mol Metab
Muñoz C, Canal C, Vizueta J, Sanchis P.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Friedrichs extension of singular symmetric differential operators

Electronic Journal of Differential Equations, 2023
Qinglan Bao, Guangsheng Wei, Anton Zettl
doaj