Results 81 to 90 of about 413,827 (305)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Complexity measures for regular expressions

Proceedings of the sixth annual ACM symposium on Theory of computing - STOC '74, 1974
Several measures of the complexity of a regular expression are defined. (Star height and number of alphabetical symbols are two of them.) Upper and lower estimates for the complexities of expressions for certain sets of paths on graphs are derived.
Andrzej Ehrenfeucht, H. Paul Zeiger
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Regular expression based pattern extraction from a cell - Specific gene expression data

Informatics in Medicine Unlocked, 2019
Cancer cells are formed when active genes stop functioning properly. Timely activation of a gene is governed through the combined effort of multiple Transcription Factors (TFs). TFs are proteins that bind on DNA in a sequence-specific manner.
Suja Subramanian, Tessamma Thomas
doaj   +1 more source

Rewriting extended regular expressions

Theoretical Computer Science, 1993
We consider an extended algebra of regular events (languages) with intersection besides the usual operations. This algebra has the structure of a distributive lattice with monotonic operations; the latter property is crucial for some applications. We give a new complete Horn equational axiomatization of the algebra and develop some term-rewriting ...
Valentin M. Antimirov, Peter D. Mosses
openaire   +2 more sources

Regular Expression: Pocket Reference

, 2007
This handy little book offers programmers a complete overview of the syntax and semantics of regular expressions that are at the heart of every text-processing application.
Stubblebine, Tony
core  

Sound regular expression semantics for dynamic symbolic execution of JavaScript [PDF]

, 2019
Support for regular expressions in symbolic execution-based tools for test generation and bug finding is insufficient. Common aspects of mainstream regular expression engines, such as backreferences or greedy matching, are ignored or imprecisely ...
Blake Loring, Loring, Blake, Johannes Kinder, Mitchell, Duncan, Duncan Mitchell, Kinder, Johannes   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source