Results 81 to 90 of about 119,419 (266)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Tikrit Journal of Pure Science, 2020 Let R be a commutative ring, the Pseudo – Von Neumann regular graph of the ring R is define as a graph whose vertex set consists of all elements of R and any two distinct vertices a and b are adjacent if and only if , this graph is denoted by P-VG(R ...
Nermen J. Khalel, Nabeel E. Arif
doaj +1 more source
Classification of graphs by regularity
Journal of Combinatorial Theory, Series B, 1981 AbstractWe give a classification of graphs by two parameters s and t such that a graph is regular iff t ≥ 2, edge-regular iff t ≥ 3, and distance regular of diameter δ iff s = δ, t ≥ 2δ − 2. We investigate the algebra of polynomials in the adjacency matrix and relate to every graph a family of orthogonal polynomials. This generalizes various results on
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
New areas of fixed point results for multi-valued mappings and its applications [PDF]
Mathematics and Computational SciencesIn this paper, the notion of limit property (Tayyab kamran, 2004) and some notions and theorems (Tayyab kamran & Calogero Vetro & Muhammad Usman Ali & Mehwish Waheed, 2017) on metric space are generalized for multi-valued function on S-m spaces.
Akbar Pourgholam, Hojjat Afshari
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Cogrowth of regular graphs [PDF]
Proceedings of the American Mathematical Society, 1992 Let G \mathcal {G} be a
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Proof of a conjecture on edge coloring of the Kneser graph K(t, 2) [PDF]
Discrete Mathematics Letters, 2023 L. Panneerselvam +3 more
doaj +1 more source