Results 161 to 170 of about 1,772,421 (241)

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Management of critical care emergencies in children with autism spectrum disorder. [PDF]

World J Crit Care Med
Al-Beltagi M, Saeed NK, Bediwy AS, Alhawamdeh R, Elbeltagi R.   +4 more
europepmc   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Health Care Access and Use Among Adults Experiencing Homelessness.

JAMA Health Forum
Fields JD, Assaf RD, Nguyen KH, Platamone CC, Pottebaum JM, Giannola J, Kushel MB.   +6 more
europepmc   +1 more source

De-identification of clinical notes with pseudo-labeling using regular expression rules and pre-trained BERT. [PDF]

BMC Med Inform Decis Mak
An J, Kim J, Sunwoo L, Baek H, Yoo S, Lee S.   +5 more
europepmc   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Automating the Addiction Behaviors Checklist for Problematic Opioid Use Identification.

JAMA Psychiatry
Chatham AH, Bradley ED, Troiani V, Beiler DL, Christy P, Schirle L, Sanchez-Roige S, Samuels DC, Jeffery AD.   +8 more
europepmc   +1 more source

Telehealth Perceived Benefits and Self-Efficacy Do Not Mediate the Effects of Demographic, Health, and Social Determinants on Telehealth Use of Low-Income African American and Latino Residents of Public Housing in Los Angeles. [PDF]

Healthcare (Basel)
Cobb S, Dillard A, Yaghmaei E, Bazargan M, Assari S.   +4 more
europepmc   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Challenges of blinding in clinical balneology trials: a scoping review. [PDF]

BMC Complement Med Ther
Szendi K, Lohner S, Szenczi Á, Murányi E, Berényi K, Németh B.   +5 more
europepmc   +1 more source