Results 21 to 30 of about 246,419 (266)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Enhancing Regular Expressions For Polish Text Processing

open access: yesComputer Science, 2009
The paper presents proposition of regular expressions engine based on the modified Thompson’salgorithm dedicated to the Polish language processing.
Krzysztof Dorosz, Anna Szczerbińska
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

THE STATUS OF THE ILLICIT DELETED SLOVENIAN CITIZENS AND LEGAL MEANS TO EXERCISE THEIR RIGHTS

open access: yesPravo, 2014
In this paper we have tried to describe the issues related to the status of the illegally deleted citizens of Slovenia as well as the remedies for the realization of their rights.
Branislav Božičković
doaj  

Types of Consonant Alternation in the Inflectional System of Soikkola Ingrian; pp. 258-275 [PDF]

open access: yesLinguistica Uralica, 2014
From the viewpoint of sound history, the Ingrian language has been considered quite regular. The focus of the present article is on regular consonant alternations in the Soikkola dialect of the Ingrian language. The first part of the article examines the
Eva Saar
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Commutative Languages and their Composition by Consensual Methods [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2014
Commutative languages with the semilinear property (SLIP) can be naturally recognized by real-time NLOG-SPACE multi-counter machines. We show that unions and concatenations of such languages can be similarly recognized, relying on – and further ...
Stefano Crespi Reghizzi   +1 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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