Results 81 to 90 of about 4,664,026 (360)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Maximally Atomic Languages [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2014
The atoms of a regular language are non-empty intersections of complemented and uncomplemented quotients of the language. Tight upper bounds on the number of atoms of a language and on the quotient complexities of atoms are known.
Janusz Brzozowski, Gareth Davies
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Generative Power and Closure Properties of Watson-Crick Grammars

open access: yesApplied Computational Intelligence and Soft Computing, 2016
We define WK linear grammars, as an extension of WK regular grammars with linear grammar rules, and WK context-free grammars, thus investigating their computational power and closure properties.
Nurul Liyana Mohamad Zulkufli   +3 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

Regular Monoidal Languages

open access: yes, 2022
We introduce regular languages of morphisms in free monoidal categories, with their associated grammars and automata. These subsume the classical theory of regular languages of words and trees, but also open up a much wider class of languages over string diagrams.
Earnshaw, Matthew, Sobociński, Paweł
openaire   +4 more sources

Positional ω-regular languages

open access: yesProceedings of the 39th Annual ACM/IEEE Symposium on Logic in Computer Science
In the context of two-player games over graphs, a language $L$ is called positional if, in all games using $L$ as winning objective, the protagonist can play optimally using positional strategies, that is, strategies that do not depend on the history of the play.
Casares, Antonio, Ohlmann, Pierre
openaire   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Expressiveness and Closure Properties for Quantitative Languages [PDF]

open access: yesLogical Methods in Computer Science, 2010
Weighted automata are nondeterministic automata with numerical weights on transitions. They can define quantitative languages~$L$ that assign to each word~$w$ a real number~$L(w)$.
Krishnendu Chatterjee   +2 more
doaj   +1 more source

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