KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients. [PDF]
BMJ OpenPapp M +6 more
europepmc +1 more source
Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook
Advanced Intelligent Discovery, EarlyView.Large language models (LLMs) are reshaping materials science. Acting as Oracle, Surrogate, Quant, and Arbiter, they now extract knowledge, predict properties, gauge risk, and steer decisions within a traceable loop. Overcoming data heterogeneity, hallucinations, and poor interpretability demands domain‐adapted models, cross‐modal data standards, and ...
Jinglan Zhang +4 more
wiley +1 more source
Low-cost embedded system for spectral power distribution reconstruction for controlled environmental agriculture using a multispectral sensor and cloud-based deep learning. [PDF]
HardwareXMorales-Guerra J +4 more
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
Making early intervention for psychosis feasible in India: Lessons from two decades of SCARF's first episode psychosis program. [PDF]
Indian J PsychiatryThara R, Mohan G, Rao S.
europepmc +1 more source
Harnessing Phase Dynamics Across Diverse Frequencies with Multifrequency Oscillatory Neural Networks
Advanced Intelligent Discovery, EarlyView.Oscillatory Neural Networks (ONNs) are an emerging computing paradigm that encodes information in the phases of coupled oscillators. Traditionally, ONNs have been investigated using homogeneous frequency oscillators. However, physical hardware implementations are inherently subject to frequency mismatches, device variability, and nonuniformities.
Nil Dinç +2 more
wiley +1 more source
Large language models for closed-library multi-document query, test generation, and evaluation. [PDF]
Front Artif IntellRandolph C, Michaleas A, Ricke DO.
europepmc +1 more source
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source