Results 61 to 70 of about 398,282 (297)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

Methods in half-linear asymptotic theory

open access: yesElectronic Journal of Differential Equations, 2016
We study the asymptotic behavior of eventually positive solutions of the second-order half-linear differential equation $$ (r(t)|y'|^{\alpha-1}\hbox{sgn} y')'=p(t)|y|^{\alpha-1}\hbox{sgn} y, $$ where r(t) and p(t) are positive continuous functions ...
Pavel Rehak
doaj  

Translational Regular Variability and the Index Function

open access: yesAxioms
This paper deals with translational regular and rapid variations. By using a new method of proving the Galambos–Bojanić-Seneta type theorems, we prove two theorems of this type for translationally regularly varying and translationally rapidly varying ...
Danica Fatić   +2 more
doaj   +1 more source

Cognitive and Non-Cognitive Predictors of the Unifed State Exam Performance of Students from Schools with Regular and Advanced Mathematical Curricula [PDF]

open access: yesPsychology in Russia: State of Art, 2018
Background. Exams such as the SAT, ACT, and GCSE are used to give an account of educational outcomes and provide a unifed criterion for university admission.
Ivan A. Voronin   +3 more
doaj   +1 more source

Generation and Detection of Multivariate Regular Variation and Hidden Regular Variation

open access: yes, 2014
We review definitions of multivariate regular variation (MRV) and hidden regular variation (HRV) for distributions of random vectors and then summarize methods for generating models exhibiting both properties. We also discuss diagnostic techniques that detect these properties in multivariate data and indicate when models exhibiting both MRV and HRV are
Das, Bikramjit, Resnick, Sidney
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Asymptotics for ultimate ruin probability in a by-claim risk model

open access: yesNonlinear Analysis, 2021
This paper considers a by-claim risk model with constant interest rate in which the main claim and by-claim random vectors form a sequence of independent and identically distributed random pairs with each pair obeying some certain dependence or arbitrary
Aili Zhang, Shuang Liu, Yang Yang
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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