Results 41 to 50 of about 95,602 (269)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
DOMINATION AND REGULARITY [PDF]
The Bulletin of Symbolic Logic, 2020 AbstractWe discuss the close relationship between structural theorems in (generalized) stability theory, and graph regularity theorems.
openaire +3 more sources
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
CoRRWe study graphs that are simultaneously regular with respect to the ordinary vertex degree and regular with respect to the triangle degree, that is, the number of triangles containing a given vertex. We call such graphs regular $K_3$-regular. We investigate the (non-)existence of regular $K_3$-regular graphs with prescribed parameters $(r_2,r_3 ...
Artem Hak +3 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
European Journal of Combinatorics, 1988 This paper studies the correspondence between topological hypermaps and algebraic hypermaps. A topological map is a decomposition of a surface into polygonal cells. A topological hypermap is a similar decomposition of an orientable surface with the ``edges'' and ``vertices'' (hyperedges and hypervertices) homeomorphic to closed discs.
David Corn, David Singerman
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Системный анализ и прикладная информатика, 2017 The statistical maximum likelihood (EM) method and the algebraic reconstruction method with simultaneous iterations (SART) are two methods of iterative tomographic reconstruction.
S. A. Zolotarev +2 more
doaj +1 more source
Mathematics, 2021 Over the last decade, regularized regression methods have offered alternatives for performing multi-marker analysis and feature selection in a whole genome context.
Juan C. Laria +8 more
doaj +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source