Results 81 to 90 of about 384,953 (220)

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

Regular overrings of regular local rings [PDF]

Transactions of the American Mathematical Society, 1972
The local factorization theorem of Zariski and Abhyankar characterizes all 2 2 -dimensional regular local rings which lie between a given 2 2 -dimensional regular local ring R R and its quotient field as finite quadratic transforms of R R .
openaire   +2 more sources

Non‐Invasive Tumor Budding Evaluation and Correlation with Treatment Response in Bladder Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study introduces a deep learning model that predicts tumor budding (TB) status in bladder cancer through the analysis of CT images. The model effectively identifies patients with high TB status, correlating with poorer prognosis and reduced responsiveness to neoadjuvant chemoimmunotherapy. This tool offers significant potential to inform prognosis
Xiaoyang Li, Chen Zou, Chunhui Wang, Cheng Chang, Yi Lin, Shuai Liang, Haoran Zheng, Libo Liu, Kai Deng, Lin Zhang, Bohao Liu, Mingchao Gao, Peicong Cai, Jianwen Lao, Longhao Xu, Daqin Wu, Xiao Zhao, Xiao Wu, Xinyuan Li, Yun Luo, Wenlong Zhong, Tianxin Lin   +21 more
wiley   +1 more source

Trustworthy Inverse Molecular Design via Alignment with Molecular Dynamics

Advanced Science, EarlyView.
Data‐driven inverse molecular design (IMD) is a promising approach to discovering new molecules with desired properties. Despite the remarkable progress, existing IMD methods lag behind in terms of trustworthiness, as indicated by their misalignment with the ground‐truth function that models the molecular dynamics.
Kevin Tirta Wijaya, Navid Ansari, Hans‐Peter Seidel, Vahid Babaei   +3 more
wiley   +1 more source

Versatile and Robust Reservoir Computing with PWM‐Driven Heterogenous R–C Circuits

Advanced Science, EarlyView.
A robust physical reservoir computing (PRC) system using pulse‐width modulation (PWM)‐encoded R–C circuits is introduced. By enabling customizable nonlinearities and timescales, this system achieves state‐of‐the‐art accuracy in chaotic, multiscale, and multiclass tasks while maintaining stability across temperature variations and device batches.
Zelin Ma, Huasen Yi, Ziping Zheng, Zhanyi Chen, Weicheng Liu, Yibing Chen, Bojun Cheng, Chang Cai, Shusheng Pan, Jun Ge   +9 more
wiley   +1 more source

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Advanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li   +12 more
wiley   +1 more source

Single‐Cell Sequencing‐Guided Annotation of Rare Tumor Cells for Deep Learning‐Based Cytopathologic Diagnosis of Early Lung Cancer

Advanced Science, EarlyView.
This study presents an innovative method to generate high‐quality, objectively annotated cytology datasets without relying on expert involvement. Large‐scale single‐cell DNA sequencing is used as an objective ground truth of cell annotation for generating an accurate, unbiased dataset of exfoliated tumor cells from bronchoalveolar lavage cytology ...
Yichun Zhao, Ruoran Qiu, Zhuo Wang, Yunyun Li, Xu Yang, Yanlin Li, Xiaohan Shen, Yun Liu, Ziqiang Chen, Qihan You, Qihui Shi   +10 more
wiley   +1 more source

High Proton Conductivity in xCuO/(1‐x)CeO2 Electrolytes Induced by CuO Self‐Nucleation and Electron‐Ion Coupling

Advanced Science, EarlyView.
This study discovers electron‐ion (E‐I) coupling in xCuO/(1‐x)CeO2(CCO), (x = 0–0.4) membranes, achieving ionic conductivity >0.15 S cm−1, with activation energy 0.28 eV and generated peak power density 900 mW cm−2 at 550 °C. Interfacial charge distribution and build‐in electric field enhanced ion transport entirely advanced the LT‐SOFC technology for ...
Muhammad Shahid Sharif, Sajid Rauf, Zuhra Tayyab, Muhammad Ahsan Masood, Yibin Tian, Muhammad Ali Kamran Yousaf Shah, Abdullah N. Alodhayb, Rizwan Raza, Bin Zhu   +8 more
wiley   +1 more source

Disturbance‐Aware On‐Chip Training with Mitigation Schemes for Massively Parallel Computing in Analog Deep Learning Accelerator

Advanced Science, EarlyView.
This study proposes novel operational schemes to solve the write disturbance issues in oxide‐semiconductor and capacitor‐based synaptic devices (6T1C devices). These schemes effectively neutralize disturbances, enabling high‐performance on‐chip training of convolutional neural networks and reducing capacitor size over 100 times.
Jaehyeon Kang, Jongun Won, Narae Han, Sangjun Hong, Jee‐Eun Yang, Sangwook Kim, Sangbum Kim   +6 more
wiley   +1 more source

A Novel Dual‐Network Approach for Real‐Time Liveweight Estimation in Precision Livestock Management

Advanced Science, EarlyView.
A novel dual‐network framework is proposed for real‐time, non‐contact liveweight estimation of pigs. By extracting contour information instead of segmented images, the method achieves high accuracy (R2 = 0.993) and an exceptional speed of 1131.6 FPS. This approach enhances automation in livestock farming, providing a scalable and efficient solution for
Ximing Dong, Caiming Zhang, Peiyuan Wang, Dexuan Chen, Gang Jun Tu, Shuhong Zhao, Tao Xiang   +6 more
wiley   +1 more source