Results 41 to 50 of about 6,996 (240)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Variational inequality formulation of the asymmetric eigenvalue problem and its solution by means of gap functions [PDF]

, 2012
: In this paper, the solution of the asymmetric eigenvalue complementarity problem (EiCP) is investigated by means of a variational inequality formulation.
Carmo P Brás, Joaquim J Júdice, Masao Fukushima, Silvério S Rosa   +3 more
core  

CQ-free optimality conditions and strong dual formulations for a special conic optimization problem [PDF]

, 2020
In this paper, we consider a special class of conic optimization problems, consisting of set-semidefinite (orK-semidefinite) programming problems, where the setKis a polyhedral convex cone.
Kostyukova, Olga, Tchemisova, Tatiana
core   +1 more source

Optimal rates for spectral algorithms with least-squares regression over Hilbert spaces [PDF]

, 2020
In this paper, we study regression problems over a separable Hilbert space with the square loss, covering non-parametric regression over a reproducing kernel Hilbert space.
Rudi, Alessandro, Lin, Junhong, Cevher, Volkan, Rosasco, Lorenzo   +3 more
core   +4 more sources

Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease

iScience
Summary: Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes.
Sunil Koundal, Xinan Chen, Zachary Gursky, Hedok Lee, Kaiming Xu, Feng Liang, Zhongcong Xie, Feng Xu, Hung-Mo Lin, William E. Van Nostrand, Xianfeng Gu, Rena Elkin, Allen Tannenbaum, Helene Benveniste   +13 more
doaj   +1 more source

Action functionals that attain regular minima in presence of energy gaps

Discrete and Continuous Dynamical Systems, 2007
We present three simple regular one-dimensional variational problems that present the Lavrentiev gap phenomenon, i.e., inf$\{\int_a^b L(t,x,\dot x): x\in W_0^{1,1}(a,b)\} $< inf$\{\int_a^bL(t,x,\dot x): x\in W_0^{1,\infty}(a,b)\}$ (where $ W_0^{1,p}(a,b)$ denote the usual Sobolev spaces with zero boundary conditions), in ...
openaire   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Physics-regularized deep learning framework for floor impact sound prediction in residential buildings: A civil engineering approach

Results in Engineering
Inter-floor noise in multi-family residential buildings constitutes a critical structural-acoustic challenge, causing health deterioration and legal disputes in densely populated urban areas.
Jongmyeong Kim, Dahye Jung, Keunsu Jeon, Yonghan Ahn, Woojae Kim, Nahyun Kwon   +5 more
doaj   +1 more source

Adaptive Observer for Coupled Wave PDE and Infinite ODE With Sampled Data and Unknown Input: Application to Brain Hemodynamics Estimation

International Journal of Adaptive Control and Signal Processing, EarlyView.
This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir, Sarah Mechhoud, Taous‐Meriem Laleg‐Kirati   +2 more
wiley   +1 more source