Results 211 to 220 of about 89,500 (309)

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

open access: yesAnnals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff   +3 more
wiley   +1 more source

Molecular Engineering Boosts Photon‐Activated Immunotherapy for Prostate Cancer Through Concurrent Pyroptosis and cGAS‐STING Pathway Activation

open access: yesAngewandte Chemie, EarlyView.
The engineered DTSe‐based photosensitizer, DZTSe, emerges as an avant‐garde molecular entity, which can distribute to both the endoplasmic reticulum and mitochondria to concurrently trigger pyroptosis and activate the cGAS‐STING pathway. This dual‐action strategy effectively reprograms the tumor microenvironment, enabling potent eradication of primary ...
Cheng Zhang   +7 more
wiley   +2 more sources

Land Use and Land Cover Stability Across Protection Regimes in a Tropical River Basin. [PDF]

open access: yesEnviron Manage
Schmitz MH   +4 more
europepmc   +1 more source

Modelling River Ice Processes in a Small-Steep-Regulated River

open access: yesJournal of Hydrology
Heyu Fang, Mark Loewen, Yuntong She
openaire   +1 more source

Natural Aging of Biomaterials in Ambient and Physiological Environments

open access: yesAdvanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Tailoring High‐Valent Iron‐Oxo Species Redox via Extended π‐Fe3d–O2p Orbital Overlapping Toward Chemical‐Efficient Water Purification

open access: yesAngewandte Chemie, EarlyView.
We address the long‐standing challenge of reactivity–selectivity trade‐off by precisely tuning the redox properties of Fe(IV), rather than simply accelerating its formation, to enable chemically efficient and low‐emission water treatment. ABSTRACT High‐valent iron oxo species (Fe(IV)) are attractive for wastewater treatment because of their high ...
Hongyu Zhou   +9 more
wiley   +2 more sources

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

open access: yesAdvanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira   +7 more
wiley   +1 more source

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