Results 311 to 320 of about 8,940,861 (343)
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Ribonucleotide reductase: regulation, regulation, regulation
Trends in Biochemical Sciences, 1992Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. It is composed of two dissimilar subunits, R1, the large subunit containing the allosteric regulatory sites, and R2, the small subunit containing a binuclear iron center and a tyrosyl free radical.
S J, Elledge, Z, Zhou, J B, Allen
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Science, 2017
Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Regulating 'Unnecessary Surgery' Regulations
Archives of Ophthalmology, 1978To the Editor. —Dr Wong's special communication entitled, "Indications for Cataract Surgery: Psycholinguistic Considerations," which appeared in the MarchArchives(96:526-528, 1978), superbly states the problems facing both patient and surgeon in the often-difficult process of deciding the point at which to intervene surgically in a patient with ...
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2017
Self-regulation encompasses a wide range of arrangements, from private ordering without resort to legal rules to state-enforced systems of delegated rules. Transaction cost analysis has been used to explain how private ordering emerges, and the advantages, but also the difficulties, of state delegation have been illustrated using a comparative approach.
CARBONARA, EMANUELA, A. Ogus
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Self-regulation encompasses a wide range of arrangements, from private ordering without resort to legal rules to state-enforced systems of delegated rules. Transaction cost analysis has been used to explain how private ordering emerges, and the advantages, but also the difficulties, of state delegation have been illustrated using a comparative approach.
CARBONARA, EMANUELA, A. Ogus
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Science, 2007
Growth factors and nutrients, particularly amino acids, regulate cell growth and proliferation in part through the serine-threonine protein kinase mTOR (mammalian target of rapamycin). Activity of mTOR is regulated through the small guanosine triphosphatase Rheb (Ras homolog enriched in brain). Bai et al .
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Growth factors and nutrients, particularly amino acids, regulate cell growth and proliferation in part through the serine-threonine protein kinase mTOR (mammalian target of rapamycin). Activity of mTOR is regulated through the small guanosine triphosphatase Rheb (Ras homolog enriched in brain). Bai et al .
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SIRTUIN 1: Regulating the regulator
Biochemical and Biophysical Research Communications, 2008Earlier analyses on the sirtuin family of histone deacetylases and its well-known member SIRT1 had their primary focus mostly on the identification of cellular targets exploring molecular mechanisms and functional networks in the control of metabolic homeostasis, differentiation, apoptosis and cell survival.
Barbara, Zschoernig, Ulrich, Mahlknecht
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Science, 1999
Major histocompatibility complex (MHC) class II antigens are almost exclusively expressed on immune cells such as dendritic cells and activated macrophages. It is known that their expression is necessary for the activation of lymphocytes and for a healthy immune response.
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Major histocompatibility complex (MHC) class II antigens are almost exclusively expressed on immune cells such as dendritic cells and activated macrophages. It is known that their expression is necessary for the activation of lymphocytes and for a healthy immune response.
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Science's STKE, 2006
MicroRNAs (miRNAs) have emerged as posttranscriptional regulators of gene expression that appear to have important roles in complex processes like development and the development of cancer. Although the abundance of miRNAs increases dramatically during development and is decreased in some cancer cells, how the production of miRNAs is ...
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MicroRNAs (miRNAs) have emerged as posttranscriptional regulators of gene expression that appear to have important roles in complex processes like development and the development of cancer. Although the abundance of miRNAs increases dramatically during development and is decreased in some cancer cells, how the production of miRNAs is ...
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The University of Chicago Law Review, 1996
Since the 1970s, there has been a tremendous growth in government regulation pertaining to risk and the environment. These efforts have emerged quite legitimately because market processes alone cannot fully address risk-related concerns.' Without some kind of regulation or liability, for example, firms lack appropriate incentives to restrict their ...
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Since the 1970s, there has been a tremendous growth in government regulation pertaining to risk and the environment. These efforts have emerged quite legitimately because market processes alone cannot fully address risk-related concerns.' Without some kind of regulation or liability, for example, firms lack appropriate incentives to restrict their ...
openaire +1 more source