Results 51 to 60 of about 35,609 (280)
Arthritis &Rheumatology, EarlyView.Objective Vacuoles E1 enzyme X‐linked autoinflammatory somatic syndrome (VEXAS) is a recently identified rare genetic disorder associated with somatic mutations in the UBA1 gene. VEXAS presents with a combination of inflammatory and hematologic manifestations, leading to increased morbidity and mortality.
Arsene Mekinian +111 more
wiley +1 more source
Banning the bulb: institutional evolution and the phased ban of incandescent lighting in Germany [PDF]
, 2014 Much academic attention has been directed at analysing energy efficiency investments through the lens of ‘behavioural failure’. These studies have challenged the neoclassical framing of regulation which emphasises the efficiency benefits of price based ...
Aman +67 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective The phase 3 MANDARA study demonstrated noninferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair +14 more
wiley +1 more source
The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities [PDF]
, 2018 O-Linked GlcNAc transferase (OGT) possesses dual glycosyltransferase-protease activities. OGT thereby stably glycosylates serines and threonines of numerous proteins and, via a transient glutamate glycosylation, cleaves a single known substrate-the so ...
Borodkin, Vladimir S. +7 more
core +4 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet +17 more
wiley +1 more source
"100 per cent, Body and Soul”:The Ability of an Agent to Act for a Competitor of his Principal [PDF]
, 2013 No abstract ...
Chalmers, J., Leverick, F.
core +2 more sources
The impacts of biological invasions
Biological Reviews, EarlyView.ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock +42 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Rapid technological change, shorter lifecycles and rising demand for electrical and electronic equipment (EEE) are increasing waste electrical and electronic equipment (WEEE) and emphasise the need for a circular economy. This paper identifies barriers and enablers of the circular transition in EEE and outlines interventions.
Aya Abdelmeguid, Lucia Corsini
wiley +1 more source
The Impact of Freedom of Speech on Conspiracy Beliefs
European Journal of Social Psychology, EarlyView.ABSTRACT Conspiracy beliefs are often portrayed as a threat to democracies. However, less is known about the extent to which the state of democracy may affect conspiracy beliefs. Hence, we investigated the impact of the societal level of freedom of speech on conspiracy beliefs. In Study 1, using aggregated nation‐level data (N = 68 countries), we found
Paul Bertin +6 more
wiley +1 more source
European Policy Analysis, EarlyView.ABSTRACT This article argues that European Union (EU) peacebuilding scholarship can benefit from organizational research on the socio‐spatial dynamics of policy implementation. It introduces a strategic‐relational heuristic to address two key gaps: the marginalization of grassroots agency in spatial analyses and the separation of strategy from ...
Giada Lagana, Sioned Pearce
wiley +1 more source