Results 151 to 160 of about 249,251 (301)

Gold Nanoparticles Supported on Poly(Phenylene Oxide) as Selective and Versatile Catalyst for Hydroamination of Arylacetylenes with Anilines

open access: yesEuropean Journal of Inorganic Chemistry, EarlyView.
Gold nanoparticles supported on poly(2,6‐dimethyl‐1,4‐phenylene oxide) (AuNPs‐PPO) demonstrates efficient and selective hydroamination, with performance tuned by reaction conditions and substrate design. Electron‐withdrawing substituents enhance conversion while preserving E‐imine selectivity, highlighting a key role of intermediate acidity.
Marta Aversa   +8 more
wiley   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

open access: yesEpilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo   +7 more
wiley   +1 more source

The topographical distribution of spermatogonial subpopulations during the cycle of seminiferous epithelium in Macaca Fascicularis. [PDF]

open access: yesBiol Reprod
Palazzoli M   +7 more
europepmc   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

open access: yesEpilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza   +4 more
wiley   +1 more source

Transcriptomic Analysis Reveals the Beneficial Effects of Spermidine in an ALS Mouse Model. [PDF]

open access: yesBiomolecules
Fiorucci C   +14 more
europepmc   +1 more source

Perspectives on the burden of drug‐resistant epilepsy and treatment priorities: Findings from a multistakeholder survey

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) imposes a significant burden on patients and their caregivers. This study aimed to explore the concerns and perceptions of healthcare providers (HCPs), patients, and caregivers regarding the burden of disease and quality of life (QoL) in patients with DRE.
Simona Lattanzi   +6 more
wiley   +1 more source

Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study

open access: yesEpilepsia Open, EarlyView.
Abstract This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2‐q13.1 duplication or deletion syndromes (15q‐DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5
Emanuele Cerulli Irelli   +14 more
wiley   +1 more source

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