Results 181 to 190 of about 4,194,617 (361)

Welsh Government Consultation: The School Performance Information (Wales) (Amendment) Regulations 2020 [PDF]

, 2020

core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Living with Leave Part I: Intermittent Leave [PDF]

, 2005
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

On Short-Term Contracts Regulations [PDF]

We present a theoretical as well as empirical analysis of the impact of employment regulations on permanent and temporary employment. We consider three different forms of such regulations, namely insider protection, fixed term contract regulations, and ...
Luca Nunziata, Stefano Staffolani
core  

Impact of coverage of drug availability regulations across the supply chain cycle in Saudi Arabia. [PDF]

Saudi Pharm J
Alyousef A, Al Masoud M, Alturki M, Shakeel F, Alshehri S.   +4 more
europepmc   +1 more source

Tailored Regulation of Graphite Microcrystals via Tandem Catalytic Carbonization for Enhanced Electrochemical Performance of Hard Carbon in the Low‐Voltage Plateau [PDF]

Limin Zhou, Gaoyue Zhang, Chenchen Xu, Junxiao Li, Yanyan Liu, Baojun Li, Ao Wang, Kang Sun   +7 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Internal Revenue Service’s Proposed Phased Retirement Regulations: Summary of Comments [PDF]

, 2005
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

Policy gap: most child-appealing packaged food products in Canada will display a 'high in' front-of-package nutrition symbol. [PDF]

Public Health Nutr
Jeong H, Mulligan C, Vergeer L, Lee JJ, L'Abbe MR.   +4 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source