Results 151 to 160 of about 2,668,555 (395)

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Cell, 2004
Jing Yang, Sendurai A Mani, Joana Liu Donaher, Sridhar Ramaswamy, R. Itzykson, C. Côme, P. Savagner, I. Gitelman, A. Richardson, R. Weinberg   +9 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer’s disease [PDF]

, 2023
Ting Wang, Yun-Qiang Zhou, Yong Wang, Liang Zhang, Xiang Zhu, Xiuyan Wang, Jinghui Wang, Lin-Kun Han, Jian Meng, Xian Zhang, Hong Luo, Qilin Ma, Zhanxiang Wang, Yun‐wu Zhang, Yun-Wu Zhang, 厦门大学附属第一医院福建省脑科疾病临床医学研究中心, 福建 厦门 361003, 中国   +15 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Integrated versus Separated Regulation: An Application to the Water Industry [PDF]

The regulation of monopolistic firms has been widely investigated in the economic literature. Particular emphasis has been placed on the relationship between the regulated monopolist and the regulator.
David Bartolini
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

ZntR is a critical regulator for zinc homeostasis and involved in pathogenicity in Riemerella anatipestifer

Microbiology Spectrum
Zinc (Zn2+) is essential for all bacteria, but excessive Zn2+ levels are toxic. Bacteria maintain zinc homeostasis through regulators, such as Zur, AdcR, and ZntR.
Hongmeng Ma, Mengying Wang, Yizhou Yao, Shutong Zhang, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Bin Tian, Xumin Ou, Di Sun, Yu He, Zhen Wu, Ling Zhang, Yanling Yu, Anchun Cheng, Mafeng Liu   +21 more
doaj   +1 more source

Health Care Providers Payments Regulation when Horizontal and Vertical Differentiation Matter [PDF]

This paper analyzes the regulation of payment schemes for health care providers competing in both quality and product differentiation of their services.
Bardey, David, Canta, Chiara, Lozachmeur, Jean-Marie   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source