Results 251 to 260 of about 1,489,667 (310)

Determination of the transcription unit landscape and associated regulatory elements in <i>Methylosinus sporium</i> 5. [PDF]

Microbiol Spectr
Bae J, Song D-U, Lee H, Lee S-G, Cho B-K.   +4 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease. [PDF]

Cell Rep Med
Fontana L, Martinucci P, Amistadi S, Felix T, Mombled M, Tachtsidi A, Corre G, Chalumeau A, Hardouin G, Martin J, Romano O, Amendola M, Antoniou P, Miccio A.   +13 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Massively parallel characterization of transcriptional regulatory elements. [PDF]

Nature
Agarwal V, Inoue F, Schubach M, Penzar D, Martin BK, Dash PM, Keukeleire P, Zhang Z, Sohota A, Zhao J, Georgakopoulos-Soares I, Noble WS, Yardımcı GG, Kulakovskiy IV, Kircher M, Shendure J, Ahituv N.   +16 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia. [PDF]

Genome Biol
Anwar R, Pande A, Singh M, Huang Z, Hallett E, Xie Y, Gellhaus A, Herse F, Nonn O, Gauster M, Raskó T, Selbach M, Verlohren S, Staff AC, Dechend R, Pecks U, Blois SM, Hurst LD, Izsvák Z.   +18 more
europepmc   +1 more source

Multiple cis-regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis. [PDF]

FEBS J
Chen J, Takamiya M, Hendriks A, Beil T, Várnai C, Diotel N, Rastegar S.   +6 more
europepmc   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis-Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish. [PDF]

Adv Sci (Weinh)
Shi J, Lai F, Shen Z, Zhang X, Wang H, Liu W, Wang Y, Li K, Li G, Fang Y, Liu JX.   +10 more
europepmc   +1 more source