Results 71 to 80 of about 8,002,490 (253)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Father-Child Conflict and Chinese Adolescent Depression: A Moderated Mediation Model

Frontiers in Psychology, 2021
To investigate the effects of father-child conflict and regulatory emotional self-efficacy (RESE) on Chinese adolescent depression, 654 middle-school students were measured.
Cong Peng, Jianwen Chen, Huifen Wu, Yan Liu, Yan Liu, Youguo Liao, Youguo Liao, Yuqin Wu, Xintong Zheng   +8 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Body appreciation and regulatory emotional self efficacy in the association between physical exercise and social anxiety among Chinese college students

Scientific Reports
Social anxiety is a salient psychological concern among college students and is closely related to interpersonal adjustment and emotional well-being. This cross-sectional study examined the association between physical exercise and social anxiety among ...
Xiaolong Zhang, Yufeng Han, Hengyu Li, Yinjia Li, Lingyuan Li, Weijie Gao   +5 more
doaj   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Aging and Interpersonal Strain: The Role of Self-Efficacy and Social Drivers of Inclusive Workplaces

Social Sciences
As the global workforce ages and multiple generations collaborate in workplaces, addressing the unique needs of diverse age groups becomes critical.
Valentina Sommovigo, Valentina Rosa, Valentina Alfano, Andrea Laudadio, Laura Borgogni   +4 more
doaj   +1 more source

Sub‐Second Ratiometric Fluorescence Imaging of Histamine Dynamics in Living Cells via a Supramolecular Probe

Advanced Science, EarlyView.
A tailored tripartite supramolecular ratiometric probe, engineered by modulating the fluorogenic guest's cationic locus, enables ultrafast histamine monitoring in living cells. Utilizing a competitive displacement mechanism, this system achieves a sub‐second response time with high selectivity.
Chenming Chan, Yujie Han, Yu‐Fei Song, Chunlei Jiang, Qi‐Wei Zhang   +4 more
wiley   +1 more source

The Protective Role of Empathy and Emotional Self-efficacy in Predicting Moral Disengagement in Adolescents Separated from Illegal Armed Groups

Anuario de Psicología Jurídica, 2021
The multiple scenarios of violence in Colombia expose minors to acts of abuse, violation of their fundamental rights, and forced recruitment by illegal armed groups.
Anyerson S. Gómez Tabares, Nicolasa M. Durán Palacio   +1 more
doaj   +1 more source

Self-regulatory efficacy and sources of efficacy in elementary school pupils : Self-regulatory experiences in a population sample and pupils with attention and executive function difficulties

, 2019
In this study, we examined self-regulatory efficacy and sources of self-efficacy (mastery experiences, vicarious experiences, social persuasion and physiological/emotional states) and the relationships between self-efficacy and its sources among ...
Westerholm, Jari, Aro, Tuija, Viholainen, Helena, Koponen, Tuire, Tolvanen, Asko, Aro, Mikko, Paananen, Mika   +6 more
core   +1 more source

AI‐Based Immortality: The Ethical Advantage of the Aretai Approach

AI &Innovation, EarlyView.
ABSTRACT The convergence of artificial intelligence, digital identity technologies, and biogerontological ambitions has produced a novel set of philosophical problems that have not yet been adequately addressed within mainstream bioethical discourse. Digital life extension—encompassing AI‐generated avatars, neural data preservation, mind uploading, and
Mirko Daniel Garasic
wiley   +1 more source