Results 121 to 130 of about 867,676 (291)
Frontiers in Marine ScienceIntroductionEncouraging consumer participation in marine recreational sport activities is recognized as a key strategy for boosting both local and regional economies.
Minghuan Shou, Jiawei Xu
doaj +1 more source
Asset correlations: shifting tides. [PDF]
The Basel II accord outlines a general framework for determining regulatory capital requirements for credit risk portfolios. Different obligors usually operate independent socio-economic environments and these structural correlations are the main reason ...
Chernih, A +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Competitive titration in living sea urchin embryos of regulatory factors required for expression of the CyIIIa actin gene [PDF]
, 1990 Previous studies have located some twenty distinct sites within the 2.3 kb 5' regulatory domain of the sea urchin CyIIIa cytoskeletal actin gene, where there occur in vitro high-specificity interactions with nuclear DNA-binding proteins of the embryo ...
Anderson, Roger +5 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in Arabidopsis thaliana. [PDF]
, 2019 Contrary to previous assumptions that most mutations are deleterious, there is increasing evidence for persistence of large-effect mutations in natural populations.
Cooper, Martha D +6 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Regulatory Fit: Impact on Anxiety, Arousal, and Performance in College-Level Soccer Players. [PDF]
Int J Exerc Sci, 2020 Leitzelar BN +4 more
europepmc +1 more source
Can Brazilian Firms Survive the Chinese Challenge: Effects of Globalization on Markets, Strategies, and Performance [PDF]
, 2011 Purpose – The purpose of this paper is to apply the structure-conduct-performance theory and the strategic fit concept to examine the effects of globalization on markets, strategies, and performance of business-to-consumer firms in Brazil.
Akhter, Syed H. +1 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source