Results 131 to 140 of about 1,617,487 (313)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The poultry and pig sector in Argentina : husbandry practice and animal welfare [PDF]

This report gives an overview of the current husbandry and management practices in the poultry and pig sector in Argentina related to animal welfare. The research centered on a description of the broiler, layer and pig sector in Argentina, the regulatory
Barilatti, M.M., Becerra, M.M.T., Daziano, M., Horne, P.L.M., van, Hoste, R., Martino, L.D.C., Senesi, S.I., Wagenberg, C.P.A., van, Winter, M.A., de   +8 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Antibiotic use in paediatrics

Exploratory Research in Clinical and Social Pharmacy, 2021
Alexander Anaba, Babafunso A. Adenuga
doaj   +1 more source

Digital policy and Nigeria’s Platform Code of Practice: towards a radical co-regulatory turn

Data & Policy
This study examines Nigeria’s National Information Technology Development Agency Code of Practice for Interactive Computer Service Platforms as one of Africa’s first push towards digital and social media co-regulation. Already established as a regulatory
Vincent Obia
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Veterinary medicinal product regulation in sub-Saharan Africa: identifying barriers and opportunities for enhancing VMP regulatory systems

Frontiers in Veterinary Science
Effective regulation of veterinary medicines is essential to ensure veterinarians and animal keepers have access to assured quality, safe and effective products to prevent and treat animal disease.
Alison Z. Pyatt, Suzanne Eckford, Noel Joseph, S. Peter Borriello, Osi Oyati   +4 more
doaj   +1 more source

Good Regulatory Lags for Price Cap and Rolling Cap contracts [PDF]

Price caps are a popular form of monopoly price regulation. One of its disadvantages is the perverse incentives that regulated firms might have to scamp on cost reducing effort during the last years before a price review. In order to avoid this problem a
Andres Gomez Lobo, Jose Luis Lima R
core  

Educational influences in learning with visual narratives [PDF]

, 2006
In this presentation, we intend to show, through the use of digital video, our understanding of ontological values of a web of betweenness and pedagogy of the unique (Farren, 2004) as they are lived in practice with students, in this case, practitioner ...
Farren, Margaret, Whitehead, Jack
core