Results 51 to 60 of about 2,746,254 (360)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Computational neurorehabilitation: modeling plasticity and learning to predict recovery [PDF]

, 2016
Despite progress in using computational approaches to inform medicine and neuroscience in the last 30 years, there have been few attempts to model the mechanisms underlying sensorimotor rehabilitation.
Burdet, E, Casadio, M, Krakauer, JW, Kwakkel, G, Lang, CE, Reinkensmeyer, DJ, Schweighofer, N, Swinnen, SP, Ward, NS   +8 more
core   +5 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Haptic Bracelets: Gait rehabilitation after Stroke [PDF]

, 2016
Restoring mobility and rehabilitation of gait are high priorities for rehabilitation of neurological conditions. Cueing using metronomic rhythmic sensory stimulation has been shown to improve gait, but most versions of this approach have used auditory ...
Georgiou, Theodoros, Holland, Simon, van der Linden, Janet   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Comparison of knowledge non-medical and medical students about the sport of people with disabilities

Journal of Education, Health and Sport, 2018
Introduction and aim: Physical activity is a very important part of everyone's life. It has positive effect on the functioning of the body of both healthy people and people with disabilities.
Agnieszka Jacykowska, Magdalena Gębska
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Longitudinal Validation of a Specific Measure of Fear Avoidance in Athletes: Predicting Time from Injury to Return to Sports Competition

Journal of Pain Research, 2023
Noémie Tito, Erica Porter, Tristan Castonguay, Geoffrey Dover Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, CanadaCorrespondence: Geoffrey Dover, Department of Health, Kinesiology, and Applied Physiology ...
Tito N, Porter E, Castonguay T, Dover G
doaj  

Feasibility of Early Functional Rehabilitation in Acute Stroke Survivors using the Balance-Bed – A Technology that Emulates Microgravity

Frontiers in Systems Neuroscience, 2015
Evidence-based guidelines recommend early functional rehabilitation of stroke patients when risk of patient harm can be managed. Current tools do not allow balance training under load conditions sufficiently low for acute stroke patients. This single-arm
Lars I.E. Oddsson, Lars I.E. Oddsson, Lars I.E. Oddsson, Marsha Joyce Finkelstein, Sarah eMeissner   +4 more
doaj   +1 more source

Therapeutic Potential of Haptic TheraDrive: An Affordable Robot/Computer System for Motivating Stroke Rehabilitation [PDF]

, 2014
There is a need for increased opportunities for effective neurorehabilitation services for stroke survivors outside the hospital environment. Efforts to develop low-cost robot/computer therapy solutions able to be deployed in home and community ...
Johnson, Michelle J., Nagurka, Mark L., Theriualt, Andrew   +2 more
core   +2 more sources