Results 21 to 30 of about 89,332 (165)

Using the nonhuman primate model of HCMV to guide vaccine development. [PDF]

, 2014
The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the ...
Barry, Peter A, Deere, Jesse D
core   +3 more sources

Studying Disease Reinfection Rates, Vaccine Efficacy and the Timing of Vaccine Rollout in the context of Infectious Diseases [PDF]

arXiv, 2023
Qatar has undergone distinct waves of COVID-19 infections, compounded by the emergence of variants, posing additional complexities. This research uniquely delves into the varied efficacy of existing vaccines and the pivotal role of vaccination timing in the context of COVID-19.
arxiv  

Evidence of continued injecting drug use after attaining sustained treatment-induced clearance of the hepatitis C virus: implications for reinfection [PDF]

, 2015
Background: People who inject drugs (PWID) are at the greatest risk of hepatitis C virus (HCV) infection, yet are often denied immediate treatment due to fears of on-going risk behaviour.
Adrian J. Stanley, Amanda Weir, Andrew Fraser, Arain, Aspinall, Chisholm, Dalgard, David J. Goldberg, EASL, Esther J. Aspinall, Grady, Grebely, Hamish Innes, Health Protection Agency, Heather Valerio, Hope, Innes, Innes, Innes, Innes, Irish, Iversen, James Lewsey, John F. Dillon, Kendrick, Lloyd-Smith, Martin, Martin, Martin, Mathers, McDonald, McDonald, Nelson, Nicholas Kennedy, Palepu, Palepu, Peter Bramley, Peter C. Hayes, Peter R. Mills, Ray Fox, Samuel Allen, Scottish Government Health Department, Sharon J. Hutchinson, Stephen T. Barclay, University of the West of Scotland   +44 more
core   +3 more sources

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources

A systematic review of the evidence for single stage and two stage revision of infected knee replacement [PDF]

, 2013
BACKGROUND: Periprosthetic infection about the knee is a devastating complication that may affect between 1% and 5% of knee replacement. With over 79 000 knee replacements being implanted each year in the UK, periprosthetic infection (PJI) is set to ...
A Beswick, A Ocguder, A Trampuz, AA Haleem, AA Hofmann, AG Rosenberg, AH Wilde, AJ Johnson, Andrew P Sprowson, AT Rasul Jr, BD Springer, CJ Wang, CL Romano, CM Jhao, CR Gooding, DJ Jaekel, DT Tsukayama, E Jamsen, FF Buechel, FS Haddad, G Von Foerster, GA Macheras, GC Babis, GH Westrich, GS Van Thiel, H Husted, H Lu, H Segawa, H-R Choi, H-T Huang, Health Protection Agency, Helen Parsons, I Byren, IS Vanhegan, J Cordero-Ampuero, J Gardner, J Lopez-Contreras, J Parvizi, J Parvizi, J Singer, J Tanner, JA Anderson, JABR Rand, James PM Masters, JH Lonner, JK Lee, JM Cuckler, JN Insall, K Hirakawa, KO Oduwole, LA Whiteside, LS Borden, M Silva, M Villanueva-Martinez, MA Mont, MAR Freeman, MC MacAvoy, MF Kurd, MG Freeman, MG Wilson, MH Henderson Jr, Mike Reed, Nicholas A Smith, NV Kalore, P Baker, P Dixon, Pedro Foguet, R Ferrari, RH Walker, RL Barrack, RMD Meek, RP Evans, RP Pitto, RT Goldman, RW Parkinson, S Bengtson, S Gulhane, S Kohl, S-J Park, SB Goksan, SJ Volin, SM Durbhakula, SM Kurtz, SMJ Mortazavi, T Bauer, T Mahmud, TK Fehring, TWB Kim, V Pascale, WJ Bose, WJ Hart, WO Jackson, Y-P Su, YC Hsu, Z Wan   +94 more
core   +1 more source

Reinfection and low cross-immunity as drivers of epidemic resurgence under high seroprevalence: a model-based approach with application to Amazonas, Brazil [PDF]

arXiv, 2021
This paper introduces a new multi-strain epidemic model with reinfection and cross-immunity to provide insights into the resurgence of the COVID-19 epidemic in an area with reportedly high seroprevalence due to a largely unmitigated outbreak: the state of Amazonas, Brazil.
arxiv  

Survivor: A Fine-Grained Intrusion Response and Recovery Approach for Commodity Operating Systems [PDF]

Proceedings of the 35th Annual Computer Security Applications Conference. ACM, 2019. p. 762-775, 2019
Despite the deployment of preventive security mechanisms to protect the assets and computing platforms of users, intrusions eventually occur. We propose a novel intrusion survivability approach to withstand ongoing intrusions. Our approach relies on an orchestration of fine-grained recovery and per-service responses (e.g., privileges removal).
arxiv   +1 more source

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. [PDF]

, 2007
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection.
Imwong, M, Snounou, G, Pukrittayakamee, S, Tanomsing, N, Kim, J R, Nandy, A, Guthmann, J P, Nosten, F, Carlton, J, Looareesuwan, S, Nair, S, Sudimack, D, Day, N P J, Anderson, T J C, White, N J   +14 more
core   +2 more sources

Potential 3rd COVID Wave in Mumbai: Scenario Analysis [PDF]

arXiv, 2021
The second wave of Covid-19 that started in mid-February 2021 in Mumbai is now subsiding. Increasingly the focus amongst the policy makers and general public is on the potential third wave. Due to uncertainties regarding emergence of new variants and reinfections, instead of projecting our best guess scenario, in this report we conduct an extensive ...
arxiv  

Assessing optimal target populations for influenza vaccination programmes: an evidence synthesis and modelling study. [PDF]

, 2013
BACKGROUND: Influenza vaccine policies that maximise health benefit through efficient use of limited resources are needed. Generally, influenza vaccination programmes have targeted individuals 65 y and over and those at risk, according to World Health ...
Baguelin, Marc, Camacho, Anton, Demiris, Nikolaos, Edmunds, W John, Flasche, Stefan, Miller, Elizabeth   +5 more
core   +3 more sources