Results 141 to 150 of about 1,816,503 (312)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Studies of Reinforced Concrete Beams and Slabs Reinforced with Steel Plates [PDF]

, 1957
United States Air ForceContract AF 33(600 ...
Casillas Garcia De Leon, Juan, Khachaturian, N., Siess, C.P.   +2 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Novel HfxTa1−xC solid solution nanowire toughened HfC coating: An effective strategy for synchronous enhanced mechanical and anti-ablation performance

Journal of Advanced Ceramics
Ultra-high-temperature ceramic nanowires have shown increasing potential for use as thermal structural components. Herein, novel single-crystal Hf0.5Ta0.5C solid solution nanowires were synthesized and incorporated with a HfC coating to construct a ...
Hui Chen, Yulei Zhang, Yanqin Fu, Wenhan Gai, Junhao Zhao, Haohui Zhang   +5 more
doaj   +1 more source

Reinforcement Unlearning

Proceedings 2025 Network and Distributed System Security Symposium
Machine unlearning refers to the process of mitigating the influence of specific training data on machine learning models based on removal requests from data owners. However, one important area that has been largely overlooked in the research of unlearning is reinforcement learning.
Ye, Dayong, Zhu, Tianqing, Zhu, Congcong, Wang, Derui, Gao, Kun, Shi, Zewei, Shen, Sheng, Zhou, Wanlei, Xue, Minhui   +8 more
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

NEW REINFORCING BAR OF RUP “BMZ” PRODUCTION

Литьë и металлургия, 2004
The technology of conversion of new kinds of hardware with profile of new type, which will allow to increase considerably the mechanical properties of concrete components and to enhance the steel economy, is considered in the article.
N. V. Andrianov, V. A. Matochkin, A. N. Bondarenko, V. A. Tishchenko, I. N. Tihonov, V. Z. Meshkov, V. S. Gumeniuk, G. N. Sudakov   +7 more
doaj  

Tunnels in Gediminas Hill (Vilnius, Lithuania): Evaluation of a New Tunnel Found in 2019

Buildings
This article provides a concise overview of the existing tunnels located within the historic cultural heritage site of Gediminas Hill in Vilnius, with particular emphasis on the implications of a recently discovered tunnel.
Šarūnas Skuodis, Mykolas Daugevičius, Jurgis Medzvieckas, Arnoldas Šneideris, Aidas Jokūbaitis, Justinas Rastenis, Juozas Valivonis   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source