Results 51 to 60 of about 309,314 (246)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Nanostructured Hydrogels by Blend Electrospinning of Polycaprolactone/Gelatin Nanofibers

Nanomaterials, 2018
Nanofibrous membranes based on polycaprolactone (PCL) have a large potential for use in biomedical applications but are limited by the hydrophobicity of PCL. Blend electrospinning of PCL with other biomedical suited materials, such as gelatin (Gt) allows
Lode Daelemans, Iline Steyaert, Ella Schoolaert, Camille Goudenhooft, Hubert Rahier, Karen De Clerck   +5 more
doaj   +1 more source

Reinforcement bar reinforcement

Будівництво, матеріалознавство, машинобудування, 2019
В статье указан способ закрепления арматурных стержней при помощи акрилового клея в зависимости от жизнеспособности клеящего состава и диаметра заделываемого стержня. Исследованы когезионные и адгезионные свойства акриловых клеев.
Dushin, V. V., Pigul, O. V., Lyapina, A. N.   +2 more
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Life Cycle and Cost Analysis of Eco-Friendly Telecommunication Poles: From Waste to Infrastructure

Proceedings
Telecommunications are essential to modern society, enabling real-time information exchange, connecting people, and driving economic and social development [...]
Hector Gabriel Vieira Nunes, Inês Costa, Bruno Silva, Diogo Martins, Bruno Rodrigues, Rui Gonçalves, Catarina Basto-Silva   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Comparison and Investigation of the Behavior of Reinforced Wooden Beams with Notches at the Ends

Drvna Industrija
When manufacturing wooden beams for spanning, notches are often formed at the ends. Under load, stresses develop at these notches, often causing cracks and beam failure.
Darius Albrektas, Ernestas Ivanauskas, Nerijus Adamukaitis, Mindaugas Uščiauskas   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Water and Reinforced Effects on Slope: Case Study on District Koto Panjang, Riau, Indonesia

JGEET: Journal of Geoscience, Engineering, Environment and Technology
This paper discussed a study case related to slope stability and its analysis. The observation and also research object was a hill side on border area between West Sumatera-Riau, Indonesia.
Soewignjo Agus Nugroho, Muhamad Yusa, Bambang Sujatmoko, Andarsin Ongko   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source