Results 201 to 210 of about 160,770 (374)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Peptide Family Promotes Brain Cell Rejuvenation and Improved Cognition through Peripheral Delivery [PDF]
Alejandro Antón‐Fernández +6 more
openalex +1 more source
Autologous emulsified fat injection for rejuvenation of scars: A prospective observational study [PDF]
, 2018 Lekshmi S. Bhooshan +4 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Environmental impact of rejuvenators in asphalt mixtures containing high reclaimed asphalt content
, 2021 Marı́a Eugenia Muñoz +7 more
openalex +1 more source
Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair [PDF]
, 2020 Ning Zhang +9 more
openalex +1 more source
Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation. [PDF]
, 2023 Alexey V. Terskikh +14 more
openalex +1 more source