Results 281 to 290 of about 113,863 (329)

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Reprogramming aging: genetically enhanced mesenchymal progenitor cells show systemic rejuvenation in primates. [PDF]

Life Med
Wang H, Du Y.
europepmc   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Rheological and Chemical Effects of Waste Tire Pyrolytic Oil and Its Encapsulation as Rejuvenators on Asphalt Binders. [PDF]

Polymers (Basel)
Delgadillo R, González A, Marzal I, Concha JL, Segura C, Arteaga-Pérez LE, Norambuena-Contreras J.   +6 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Real World Case Series: Integrated Skincare With Advanced RGN-6 Serum. [PDF]

J Cosmet Dermatol
Alexis A, Beach RA, Brieva P, Guénin S, Ibrahimi OA, Rodrigues M, Woolery-Lloyd H, Callender V.   +7 more
europepmc   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging. [PDF]

Pain
Abdelkader B, Shi XQ, Zhou WBS, Castaño JD, Grant AV, Beaudry F, Zhang J.   +6 more
europepmc   +1 more source

Systemic factors in young human serum influence <i>in vitro</i> responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system. [PDF]

Aging (Albany NY)
Ritter J, Falckenhayn C, Qi M, Gather L, Gutjahr D, Schmidt J, Simm S, Kalkhof S, Hildebrand J, Bosch T, Winnefeld M, Grönniger E, Siracusa A.   +12 more
europepmc   +1 more source