Results 301 to 310 of about 160,770 (374)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

RETRACTION: Subjective Evaluation of Monopolar Radiofrequency Treatment by Patients in Aesthetic Rejuvenation. [PDF]

Skin Res Technol
europepmc   +1 more source

A Real-World Evaluation of Definisse Filler for Facial Rejuvenation in Indian Patients: The REDEFINE REJUVENATION Study. [PDF]

Cureus
Nuthalapati S, Deo J, Balani K, Pereira R, Trasi Nerurkar S, Ballani I, Bhadani S, Rathore VS, Srinivasa S, Patil CY, Kaushik I, Dadhich S, Pawar A.   +12 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Immortality Reconsidered: Clinical Challenges at the Frontier of Plastic Surgery. [PDF]

J Clin Med
Xun H, Mustoe AK, Escobar MJ, Chan Z, Moreira A, TerKonda S, Jeffers L, Lee BT.   +7 more
europepmc   +1 more source

Nephroprotective activities of Raktapunaṛnavā (Boerhavia diffusa L.) – An Ayurvedic Rejuvenative Drug: A Review

K. S. Jinesh Babu, D.K. Srinivasaprabhu
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. [PDF]

Aging Cell
Murach KA, Dungan CM, Chambers TL, Horvath S, Nandakumar J, Gladyshev VN, Pletcher SD, Dai X, Guo L.   +8 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source