Results 31 to 40 of about 841 (265)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Revealing the rejuvenation mechanism of SBS modified asphalt through combined rheology-AFM-MD-DFT analysis

Frontiers in Built Environment
This study investigates the changes in microstructure and rheological properties of SBS modified asphalt during aging and regeneration processes. The high-temperature rutting resistance and low-temperature crack resistance at different ageing stages were
Man Zhang, Man Zhang, Jingzhuo Zhao, Xu Wu, Xu Wu   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Novel approaches and materials for healing asphalt cracks

Građevinar, 2023
Premature cracks in an asphalt pavement may damage its intact structure, substantially decrease its load-bearing capacity, degrade its driving comfort and safety, and even lead to total pavement failure.
Abdulgazi Gedik, Ozgur Ozcan, Sedat Ozcanan   +2 more
doaj   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Optimization design of asphalt emulsion with rejuvenator towards a uniform distribution inside the damaged porous asphalt mixture for a better ravelling resistance

Case Studies in Construction Materials
Porous asphalt (PA) pavements usually meet the ravelling disease after opening to traffic for several years. Spraying surface treatment (ST) emulsion to PA pavement is a feasible preventive maintenance technology to alleviate this problem.
Bin Yang, Jiwang Jiang, Haopeng Wang, Zhen Leng, Xin Sui, Xi Jiang   +5 more
doaj   +1 more source

Optimization of the Calcium Alginate Capsules for Self-Healing Asphalt

Applied Sciences, 2019
It has been demonstrated that calcium alginate capsules can be used as an asphalt healing system by pre-placing rejuvenator (healing agent) into the asphalt mix and releasing the rejuvenator on demand (upon cracking). This healing mechanism relies on the
Shi Xu, Amir Tabaković, Xueyan Liu, Damian Palin, Erik Schlangen   +4 more
doaj   +1 more source

Rafting of Ni‐Based Superalloys Under Multiaxial Load as Understood by Phase‐Field Simulations and Critical Experiments

Advanced Engineering Materials, EarlyView.
Phase‐field simulations coupled with dislocation‐density‐based crystal plasticity modeling reproduce γ′ rafting behavior in single‐crystal Ni‐based superalloys under varied loading conditions. The model captures both macroscopic creep and microscopic morphology evolution, with results matching high‐temperature creep experiments.
Micheal Younan, David Bürger, Gunther Eggeler, Oleg Shchyglo, Ingo Steinbach, Muhammad Adil Ali   +5 more
wiley   +1 more source

Stretching the Printability Metric in Direct‐Ink Writing with Highly Extensible Yield‐Stress Fluids

Advanced Functional Materials, EarlyView.
This study introduces “drawability” as a new metric for assessing printability in direct‐ink writing, focusing on gap‐spanning performance and speed robustness. By designing yield‐stress fluids with high extensibility, we demonstrate that extensional strain‐to‐break significantly enhances printability.
Chaimongkol Saengow, Samya Sen, Joaquin Yus, Eliza E. Lovrich, Amanda G. Hoika, Kelly M. Chang, Arielle A. Pfeil, Nellie Haug, Amy J. Wagoner Johnson, Randy H. Ewoldt   +9 more
wiley   +1 more source

Effects of utilization of rejuvenator in asphalt mixtures containing recycled asphalt pavement at high ratios

Case Studies in Construction Materials
This study investigated the properties of asphalt mixtures, including recycled asphalt pavement, at high ratios. In addition, to improve the properties of asphalt mixtures containing recycled asphalt pavement, bitumen was modified with a rejuvenator at ...
Mehmet Saltan, Mohammad Hussain Khaliqi
doaj   +1 more source