Results 81 to 90 of about 633,065 (305)
Frontiers in MedicineAcute myeloid leukemia (AML) exhibits a pronounced ability to develop drug resistance and undergo disease relapse. Recent research has noticed that resistance to treatments could substantially be attributed to drug-tolerant persister (DTP) cells, which ...
Meng Li +3 more
doaj +1 more source
RELAPSE PRECIPITANTS, LIFE EVENTS & COPING BEHAVIORS AMONG SUBSTANCE USERS
Indian Journal of Psychiatric Nursing, 2016 Relapse is common and stressful aspect among substance abusers. In the present study there has been an attempt to study relapse precipitants, life events and coping behaviors among opioids, alcohol and multiple substance dependent men.
Rajesh Kumar, Sushil K. Maheshwari
doaj +1 more source
Joint Bone Spine, 2014 Relapsing polychondritis (RP) is a rare disease in which recurrent bouts of inflammation, in some cases followed by destruction, affect the cartilage of the ears, nose, larynx, and tracheobronchial tree. At presentation, however, arthritis is the most common manifestation and more than half the patients have no evidence of chondritis.
Puéchal, Xavier +5 more
openaire +2 more sources
Therapist's guide to evidence-based relapse prevention /
, 2007 Describes the evidence-based approaches to preventing relapse of major mental and substance-related disorders. Therapist's Guide to Evidence-based Relapse Prevention combines the theoretical rationale, empirical data, and the practical "how-to" for ...
Witkiewitz, Katie., Marlatt, G. Alan.
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Schizophrenia relapse, patient considerations, and potential role of lurasidone [PDF]
, 2016 Leslie Citrome Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA Abstract: When treating persons with schizophrenia, delaying time to relapse is a main goal.
Citrome L, Citrome, Leslie L
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients [PDF]
, 2001 Background and Objectives. Detection of PML-RAR alpha transcripts by RT-PCR is now established as a rapid and sensitive method for diagnosis of acute promyelocytic leukemia (APL), Although the majority of patients in longterm clinical remission are ...
Gameiro, P +11 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
BiomedicinesTriple-negative breast cancer (TNBC) is a heterogeneous cancer that lacks estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2) proteins.
Neya Ramanan +14 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source