Results 81 to 90 of about 476,071 (256)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Utility of a Large Series of B‐Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System

Cancer Medicine
Background In B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), chromosomal translocations are strongly associated with prognoses. RNA sequencing (RNA‐seq) is a powerful technology that reveals a close correlation between types of translocation ...
Minori Tamai, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Koshi Akahane, Kumiko Goi, Kanji Sugita, Chihiro Tomoyasu, Toshihiko Imamura, Hiroaki Goto, Takeshi Inukai   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

NSE and ProGRP Are Promising Markers for Diagnosis, Efficacy Evaluation, Follow‐Up Monitoring, and Prognosis of Small Cell Esophageal Carcinoma

Thoracic Cancer
Background To investigate the clinical implications of serum carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and pro‐gastrin‐releasing peptide (ProGRP) in small cell esophageal carcinoma (SCEC).
Di Liu, Dan Wu, Jianjiao Ni, Junhua Zhang, Suhong Xie   +4 more
doaj   +1 more source

SPREADING PATTERN OF INFECTIOUS DISEASES: SUSCEPTIBLE INFECTED RECOVERED MODEL WITH VACCINATION AND DRUG-RESISTANT CASES (APPLICATION ON TB DATA IN INDONESIA)

Barekeng
Mycobacterium tuberculosis is the causative agent of the infectious illness tuberculosis (TB). Indonesia is the world's third-highest TB burden country. TB transmission is prevented by the BCG vaccination.
Purnami Widyaningsih, Siti Roqhilu Yumaroh, Dewi Retno Sari Saputro   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Moving beyond animal models: enriched environments and human substance use disorders

Frontiers in Behavioral Neuroscience
BackgroundPreclinical studies have shown that exposure to a multisensory, stimulating environment (environmental enrichment, EE) can prevent the development of addictive behaviors and reduce the risk of relapse in animal models.
Lila Barillot, Lila Barillot, Claudia Chauvet, Emeline Chauchard, Marc Besnier, Marc Besnier, Ghina Harika-Germaneau, Ghina Harika-Germaneau, Xavier Noël, Nemat Jaafari, Nemat Jaafari, Marcello Solinas, Marcello Solinas, Armand Chatard, Armand Chatard   +14 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Comparative characteristics of quantitative and structural chromosome abnormalities at the time of diagnosis and in relapses of acute myeloid leukemias

Medičnì Perspektivi
Acute myeloid leukemias (AML) are a heterogeneous group of neoplasms of hematopoietic tissue, to determine the subtypes of which cytomorphological and cytochemical methods, immunophenotyping, cytogenetic and molecular genetic studies are carried out ...
S.V. Andreieva , K.V. Korets , I.M. Skorokhod , I.R. Hartovska, U.I. Melnyk   +4 more
doaj   +1 more source