Results 291 to 300 of about 1,690,986 (339)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Prognostic and immunological significance of CD82 in cancers with focus on hepatocellular carcinoma: A bioinformatics approach. [PDF]

Medicine (Baltimore)
Ali S, Liu S, Chen J, Ullah J, Mou G, Huang X.   +5 more
europepmc   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Growth-induced percolation on complex networks. [PDF]

PNAS Nexus
Sun H, Chen S, Xie J, Hu Y.
europepmc   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Identification of circulating tumor cells marker genes as prognostic signature in triple-negative breast cancer. [PDF]

Discov Oncol
Hu J, Zhang KM, Wang X.
europepmc   +1 more source

Editorial: Theory of mind in relation to other cognitive abilities, volume II. [PDF]

Front Psychol
Dowker A, Frye D.
europepmc   +1 more source

Dynamic taxonomy generation for future skills identification using a named entity recognition and relation extraction pipeline. [PDF]

Front Artif Intell
Gonzalez-Gomez LJ, Hernandez-Munoz SM, Borja A, Arana-Salas FA, Azofeifa JD, Noguez J, Caratozzolo P.   +6 more
europepmc   +1 more source

Enhancing cybersecurity through autonomous knowledge graph construction by integrating heterogeneous data sources. [PDF]

PeerJ Comput Sci
Alharbi H, Hur A, Alkahtani H, Ahmad HF.
europepmc   +1 more source

Global Patterns in the Evolutionary Relations Between Seed Mass and Germination Traits. [PDF]

Ecol Evol
Maleki K, Vandelook F, Saatkamp A, Maleki K, Heshmati S, Soltani E.   +5 more
europepmc   +1 more source