Results 91 to 100 of about 1,836,012 (321)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Construction and Mathematical Application of Document-Level Relationship Extraction Model Combining R-GCN and Text Features

IEEE Access
With the development of smart education, building a knowledge graph to integrate educational resources has become particularly important. However, existing sentence level relationship extraction methods are difficult to address the complex relationship ...
Zhiqin Chen
doaj   +1 more source

The effect of different tooth extraction patterns on Bolton index and occlusal relationship of skeletal Class Ⅱ malocclusion [PDF]

Kouqiang yixue
Objective To investigate the effect of different premolar extraction patterns on Bolton index and occlusal relationship of skeletal Class Ⅱ malocclusion.
SONG Ye, REN Yinting, ZHANG Yihan, HAN Jingying
doaj   +1 more source

Feature Extraction Methods in Quantitative Structure–Activity Relationship Modeling: A Comparative Study [PDF]

, 2020
Shrooq Alsenan, Isra Al-Turaiki, Alaaeldin M. Hafez   +2 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A Top-down Method of Extraction Entity Relationship Triples and Obtaining Annotated Data [PDF]

, 2022
Zhiqiang Hu, Zheng Ma, Jun Shi, Жипенг Ли, Xun Shao, Yangzhao Yang, Yong Liao, Zhenyuan Gao, Jie Zhang   +8 more
openalex   +1 more source

Foreign Direct Investment and Pollution Havens [PDF]

This study empirically investigates the causality relationship between foreign direct investment in the extractive industries and environmental pollution with specific focus on the exploration of natural gas and crude oil.
Kato John Kingston
core  

Oil cooling system for a gas turbine engine [PDF]

, 1977
A gas turbine engine fuel delivery and control system is provided with means to recirculate all fuel in excess fuel control requirements back to the aircraft fuel tank.
Coffinberry, G. A., Kast, H. B.
core   +2 more sources

Wigner representation for polarization-momentum hyperentanglement generated in parametric down conversion, and its application to complete Bell-state measurement

, 2014
We apply the Wigner function formalism to the study of two-photon polarization-momentum hyperentanglement generated in parametric down conversion. It is shown that the consideration of a higher number of degrees of freedom is directly related to the ...
Casado, A., Guerra, S., Plácido, J.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source