Results 111 to 120 of about 4,280,246 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats

Skeletal Muscle
Background Older adults exhibit a slower recovery of muscle mass following disuse atrophy than young adults. At a smaller scale, muscle fibre cross-sectional area (i.e., sarcomeres in parallel) exhibits this same pattern.
Avery Hinks, Geoffrey A. Power
doaj   +1 more source

The Financing of Innovation: Learning and Stopping [PDF]

This paper considers the financing of a research project under uncertainty about the time of completion and the probability of eventual success.The uncertainty about future success gradually diminishes with the arrival of additional funding.The ...
Bergemann, D., Hege, U.
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Morphometric Studies on Subadult Liza subviridis and Sillago sihama from Sonmiani Bay (Miani Hor), Balochistan, Pakistan

Journal of Bioresource Management, 2014
Length-weight relationship of Liza subviridis and Sillago sihama (Family: Mugilidae; Class: Pisces and Family: Sillaginidae; Class: Pisces) in subadults sampled from Somiani Bay Balochistan, Pakistan during 2002, 2003􀀃and 2006 was analyzed.
Muhammad A. Gondal , Naureen A. Qureshi , Noor U. Saher   +2 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Growth of the silverside Atherinella brasiliensis in a subtropical estuary with some insights concerning the weight-length relationship

Anais da Academia Brasileira de Ciências
Specimens of Brazilian silverside (Atherinella brasiliensis, n=9672) with a length range of 1.5 to 14.2 cm were captured in the intertidal areas of the Estuarine Complex of Paranaguá, Brazil, between August 2010 and July 2011.
BARBARA M. DE CARVALHO, JOSÉ RICARDO S. BARRADAS, NELSON F. FONTOURA, HENRY L. SPACH   +3 more
doaj   +1 more source

Normal and Abnormal Personality Traits are Associated with Marital Satisfaction for both Men and Women: An Actor–Partner Interdependence Model Analysis [PDF]

, 2010
Research has demonstrated associations between relationship satisfaction and personality traits. Using the Actor–Partner Interdependence Model, we explored associations between self-reported relationship satisfaction in couples (n = 118) and various ...
Durbin, C. Emily, Knobloch-Fedders, Lynne M., Saigal, Seema D., Stroud, Catherine B.   +3 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Length-weight relationship of five serranids from Palawan Island, Philippines [PDF]

, 2000
The parameters a and b of the length-weight relationship (LWR) of the form W=aLb are presented for five species of serranids belonging to the genus Cephalopolis.
Gonzales, B.J., Mishina, H., Palla, H.P.
core