Results 81 to 90 of about 269,371 (268)
Vibration isolation systems, considered as systems with single degree of freedom
MATEC Web of Conferences, 2017 The research considers and analyzes vibration isolation systems, whose design schemes are single degree of freedom systems, including nonlinear elements - displacement limiter and viscous damper.
Zebilila Mohammed, Chernov Jury
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Losses and orbital part of the Poynting vector of air-core modes in hollow-core fibers
Компьютерная оптикаIn our earlier works, we investigated a relationship between the formation of vortices in the transverse component of the Poynting vector of core modes and the regimes of strong localization of these modes in solid core micro-structured optical fibers ...
G.K. Alagashev +2 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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Tikrit Journal of Engineering SciencesThis research investigated the shear capacity and curvature ductility relation of high-strength reinforced concrete cantilever beams subjected to monotonic loading. Twelve cantilever beams with section dimensions of 200×300 mm were tested.
Hussein A. Merie +2 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Hydrodynamic modes in holographic multiple-axion model
European Physical Journal C: Particles and FieldsIn this paper we investigate the shear viscoelasticity and the hydrodynamic modes in a holographic solid model with several sets of axions that all break the translations spontaneously on boundary. Comparing with the single-axion model, the shear modulus
Ling-Zheng Xia, Wei-Jia Li
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