Results 31 to 40 of about 6,448,844 (299)

Body Image, Depression, and Self-Perceived Pornography Addiction in Italian Gay and Bisexual Men: The Mediating Role of Relationship Satisfaction

Mediterranean Journal of Clinical Psychology, 2021
The international literature has shown that self-perceived problematic pornography use is often related to lower levels of relationship satisfaction, as well as to higher levels of negative body image and depression. In this study, 158 Italian gay (65.8%)
Massimiliano Sommantico, Francesca Gioia, Valentina Boursier, Ilaria Iorio, Santa Parrello   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Parental relationship satisfaction, symptoms of depression and anger/hostility, and the moderating role of perceived social support—a prospective cohort study in the light of the COVID-19 pandemic

Frontiers in Psychology
BackgroundThe challenging early parenthood time and the strains of the COVID-19 pandemic negatively affected parental mental health, whereas relationship satisfaction and perceived social support acted protective.
Josephine Kümpfel, Victoria Weise, Judith T. Mack, Susan Garthus-Niegel, Susan Garthus-Niegel, Susan Garthus-Niegel   +5 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Correlates of Tertiary Student Life Satisfaction [PDF]

, 2010
What determines life satisfaction for young people? Many studies have looked at factors that correlate with an individual’s level of life satisfaction however the vast majority of those studies focused on elderly populations. The aim of this study was to
Raman, Jerode R
core  

The Satisfaction-Place Attachment Relationship: Potential Mediators and Moderators

, 2015
Researchers use place satisfaction as a dependent variable extensively since place has implications for a range of performance measures. This study reverses the relationships suggesting place satisfaction as a useful antecedent to place attachment. Place
Mavondo, F., Mavondo, F. T, Ramkissoon, H, Ramkissoon, Haywantee   +3 more
core   +1 more source

Relationship quality and cross-buying in varying levels of category similarity and complexity [PDF]

, 2008
Numerous studies have shown satisfaction and trust are the crucial antecedents of loyalty. However, the relationship between satisfaction, trust and cross-buying is not as simple as expected.
Wei Wu, Li, Chi Liu, Tsung
core   +1 more source