Results 151 to 160 of about 11,278,454 (337)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Investigation of the Effect of Relative Density on the Dynamic Modulus and Damping Ratio for Coarse Grained Soil

open access: yesApplied Sciences
As the critical dynamic parameters for soil, an extensive examination of the dynamic elastic modulus Ed and damping ratio λ in coarse-grained soil is of significant theoretical and practical importance.
Ziying Huang   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Examining Shear Behavior in Sandy Gravel Interfaces: The Role of Relative Density and Material Interactions

open access: yesBuildings
Current research on soil–structure interface properties mainly focuses on sand, clay, and silt, with little attention given to sandy gravel. In order to study the effects of relative density and interface materials on the shear behavior of the sandy ...
Zhanhai Li   +9 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Development patterns of the dynamic elastic modulus of saturated coral sand under different drainage conditions

open access: yesFrontiers in Marine Science
Long-term cyclic loading can have a significant effect on the modulus of sand, and the influence on saturated coral sand has yet to be established. In this paper, the significant influence of non-plastic fines content (FC) and relative density (Dr) on ...
Ruirong Zhou   +6 more
doaj   +1 more source

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