Results 161 to 170 of about 3,574,868 (308)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Relative efficiency of psychiatric clinics in treating cases without coercion and achieving symptom reduction. [PDF]

Eur Psychiatry
Müller C, Ziltener T, Moeller J, Lieb R, Lang U, Huber C.   +5 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The relative efficiency of staircase and stepped wedge cluster randomised trial designs. [PDF]

Stat Methods Med Res
Grantham KL, Forbes AB, Hooper R, Kasza J.   +3 more
europepmc   +1 more source

The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease. [PDF]

Alzheimers Dement (N Y), 2019
Li D, Iddi S, Aisen PS, Thompson WK, Donohue MC.   +4 more
europepmc   +1 more source

Public sector efficiency: Leveling the playing field between OECD countries [PDF]

In this paper we seek a robust methodology to measure the relative public spending efficiency of 19 OECD countries over the period 1980-2000. Based on the functional classification of government expenditure, we decompose total public spending into its ...
Adam, Antonis, Delis, Manthos D, Kammas, Pantelis   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Ultrastrong, flexible thermogalvanic armor with a Carnot-relative efficiency over 8. [PDF]

Nat Commun
Wang J, Song Y, Yu F, Zeng Y, Wu C, Qin X, Peng L, Li Y, Zhou Y, Tao R, Liu H, Zhu H, Sun M, Xu W, Zhang C, Wang Z.   +15 more
europepmc   +1 more source

Relative efficiency of precision medicine designs for clinical trials with predictive biomarkers. [PDF]

Stat Med, 2018
Shih WJ, Lin Y.
europepmc   +1 more source