Will Small-Scale Dairy Producers in Kenya Disappear Due to Economies of Scale in Production? [PDF]
There is growing policy concern regarding the competitiveness of small-scale livestock production in the wake of the contemporary livestock revolution in many developing countries.
Delgado, Christopher L. +4 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Myasthenia Gravis Impairment Index: Responsiveness, meaningful change, and relative efficiency. [PDF]
Neurology, 2017 Barnett C +4 more
europepmc +1 more source
On relative efficiency of Quasi-MLE and GMM estimators of covariance structure models [PDF]
Optimal GMM is known to dominate Gaussian QMLE in terms of asymptotic efficiency (Chamberlain, 1984). I derive a new condition under which QMLE is as efficient as GMM for a general class of covariance structure models.
Artem Prokhorov
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Rapid decay in the relative efficiency of quarantine to halt epidemics in networks. [PDF]
Phys Rev E, 2018 Strona G, Castellano C.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
End-of-life cohorts from the Dartmouth Institute: risk adjustment across health care markets, the relative efficiency of chronic illness utilization, and patient experiences near the end of life. [PDF]
Res Health Serv RegBronner KK, Goodman DC.
europepmc +1 more source
The relative efficiency of Iranian's rural traffic police: a three-stage DEA model. [PDF]
BMC Public Health, 2017 Rahimi H +6 more
europepmc +1 more source