Results 151 to 160 of about 4,381,784 (312)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Relative Entropy, Gaussian Concentration and Uniqueness of Equilibrium States. [PDF]
Entropy (Basel), 2022 Chazottes JR, Redig F.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
BEARING DEGRADATION STATE IDENTIFICATION OF LCD-HILBERT RELATIVE SPECTRUM ENTROPY
Jixie qiangdu, 2019 In order to better identification the degradation state of bearing, a degradation state feature extraction method for bearing named LCD-Hilbert relative spectrum entropy is proposed based on relative entropy for characterizing the probability ...
CHEN HuiHong
doaj
Research on the Robustness of the Chinese Input-Output Network Based on Relative Entropy Theory. [PDF]
Entropy (Basel), 2022 Li W, Wang A, Xing W.
europepmc +1 more source
Hierarchical Relative Entropy Policy Search [PDF]
, 2016 Many reinforcement learning (RL) tasks, especially in robotics, consist of multiple sub-tasks that are strongly structured. Such task structures can be exploited by incorporating hierarchical policies that consist of gating networks and sub-policies.
C. Daniel +3 more
openaire +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
DNA-influenced automated behavior detection on twitter through relative entropy. [PDF]
Sci Rep, 2022 Gilmary R +3 more
europepmc +1 more source