Results 21 to 30 of about 6,899 (189)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

On the multiplicity of isometry-invariant geodesics on product manifolds

, 2013
We prove that on any closed Riemannian manifold $(M_1\times M_2,g)$, with $\rank\Hom_1(M_1)\neq0$ and $\dim(M_2)\geq2$, every isometry homotopic to the identity admits infinitely many isometry-invariant geodesics.Comment: 17 ...
Mazzucchelli, Marco
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

On the multiplicity of non-iterated periodic billiard trajectories

, 2011
We introduce the iteration theory for periodic billiard trajectories in a compact and convex domain of the Euclidean space, and we apply it to establish a multiplicity result for non-iterated trajectories.Comment: 21 pages, 2 figures; v3: final version ...
Arnold, Babenko, Bangert, Chang, Cohen, Croft, Gromoll, Kozlov, Long, Marco Mazzucchelli, Mazzucchelli   +10 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The type numbers of closed geodesics

, 2010
A short survey on the type numbers of closed geodesics, on applications of the Morse theory to proving the existence of closed geodesics and on the recent progress in applying variational methods to the periodic problem for Finsler and magnetic ...
A. Bahri, A. Borel, A. Nabutovsky, A.B. Katok, A.I. Fet, A.S. Schwarz, A.V. Pajitnov, D. Gromoll, D.V. Anosov, D.V. Anosov, D.V. Anosov, D.V. Anosov, G. Contreras, H. Seifert, H.-B. Rademacher, H.-B. Rademacher, H.-B. Rademacher, I. A. Taimanov, I.A. Taimanov, I.A. Taimanov, I.A. Taimanov, I.A. Taimanov, J. Franks, J. Milnor, L.A. Lusternik, L.A. Lusternik, L.S. Pontryagin, L.S. Pontryagin, M. Farber, M. Gromov, M. Morse, M. Vigué-Poirrier, N. Hingston, P.G. Grinevich, R. Bott, R. Bott, S.I. Al’ber, S.P. Novikov, S.P. Novikov, S.P. Novikov, S.P. Novikov, S.P. Novikov, V. aBngert, V. Bangert, V. Bangert, V. Bangert, V. Ginzburg, V.I. Arnold, V.L. Ginzburg, V.S. Guba, V.V. Kozlov, W. Ballmann, W. Ballmann, W. Ballmann, W. Ballmann, W. Ballmann, W. Klingenberg, W. Klingenberg, W. Klingenberg, W. Ziller, Y. Long, Y. Long, Y. Long   +62 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Limitations on the smooth confinement of an unstretchable manifold

, 2000
We prove that an m-dimensional unit ball D^m in the Euclidean space {\mathbb R}^m cannot be isometrically embedded into a higher-dimensional Euclidean ball B_r^d \subset {\mathbb R}^d of radius r < 1/2 unless one of two conditions is met -- (1)The ...
Amar M. Ben, Bak P., Cartan E., Cartan E., Cerda E., E. M. Kramer, Ferus D., Gromov M., Houle P. A., Hull C. M., Kramer E. M., Lobkovsky A. E., Pomeau Y., Pomeau Y., R. P. Geroch, S. C. Venkataramani, T. A. Witten   +16 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source