Results 91 to 100 of about 3,555,142 (282)

Experimental Design and the Relative Sensitivity of BOLD and Perfusion fMRI

open access: yesNeuroImage, 2002
This paper compares the statistical power of BOLD and arterial spin labeling perfusion fMRI for a variety of experimental designs within and across subjects. Based on theory and simulations, we predict that perfusion data are composed of independent observations in time under the null hypothesis, in contrast to BOLD data, which possess marked ...
Geoffrey Karl Aguirre   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Modelling Relative Fire Sensitivity for Geodiversity Elements

open access: yesFire
The integration of geodiversity elements and contexts into fire management frameworks remains limited due to a lack of actionable tools for assessing geosite sensitivity.
Ruby O. Hoyland, Melinda T. McHenry
doaj   +1 more source

Relative Sensitivity And Cost Of Amphipod Bioassays

open access: yesProceedings OCEANS, 2005
Studies were conducted to compare the relative sensitivity of the amphipods Ampelisca abdita, Grandidierella japonica, and Rhepoxynius abronius; the differences in their sensitivity under flow-through and static testing protocols; and the relative cost of performing each type of test.
J.Q. Word   +4 more
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Design and simulation of photonic crystal fiber for highly sensitive chemical sensing applications

open access: yesOpen Engineering
Photonic crystal fibers (PCF) have demonstrated promising capabilities for liquid sensing applications owing to their distinctive optical properties. This work presents a numerical investigation of a PCF sensor optimized for discriminating water, ethanol,
Jebur Raed Sattar, Thaher Raad Hamdan
doaj   +1 more source

Analysis and filtering of phase noise in an optical frequency comb at the quantum limit to improve timing measurements

open access: yes, 2014
The sensitivity of homodyne timing measurements with femtosecond lasers is only limited by the amplitude and phase noise. We describe a novel method to analyze the phase noise of a Ti:Sapph oscillator relative to the standard quantum limit. The broadband
Fabre, Claude   +4 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Investigating the Effect of Relative Firms Profitability on Stock Return Sensitivity to Industry-Level News [PDF]

open access: yesمجله دانش حسابداری, 2014
Relative firm profitability within industry as a measure of competitiveness reflects the business strengths and weaknesses of the firm, and affects the reaction of stock returns to industry-level news.
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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