Results 61 to 70 of about 1,530,318 (247)
Experimental Design and the Relative Sensitivity of BOLD and Perfusion fMRI
NeuroImage, 2002 This paper compares the statistical power of BOLD and arterial spin labeling perfusion fMRI for a variety of experimental designs within and across subjects. Based on theory and simulations, we predict that perfusion data are composed of independent observations in time under the null hypothesis, in contrast to BOLD data, which possess marked ...
Geoffrey Karl Aguirre +3 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Increasing the information provided by probabilistic sensitivity analysis: The relative density plot
Cost Effectiveness and Resource Allocation, 2020 Background Results of probabilistic sensitivity analyses (PSA) are frequently visualized as a scatterplot, which is limited through overdrawing and a lack of insight in relative density.
Joost W. Geenen +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Modelling Relative Fire Sensitivity for Geodiversity Elements
FireThe integration of geodiversity elements and contexts into fire management frameworks remains limited due to a lack of actionable tools for assessing geosite sensitivity.
Ruby O. Hoyland, Melinda T. McHenry
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Design and simulation of photonic crystal fiber for highly sensitive chemical sensing applications
Open EngineeringPhotonic crystal fibers (PCF) have demonstrated promising capabilities for liquid sensing applications owing to their distinctive optical properties. This work presents a numerical investigation of a PCF sensor optimized for discriminating water, ethanol,
Jebur Raed Sattar, Thaher Raad Hamdan
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Investigating the Effect of Relative Firms Profitability on Stock Return Sensitivity to Industry-Level News [PDF]
مجله دانش حسابداری, 2014 Relative firm profitability within industry as a measure of competitiveness reflects the business strengths and weaknesses of the firm, and affects the reaction of stock returns to industry-level news.
doaj +1 more source