Results 91 to 100 of about 1,674,742 (295)

Validation and Calibration of Models for Reaction-Diffusion Systems

, 1997
Space and time scales are not independent in diffusion. In fact, numerical simulations show that different patterns are obtained when space and time steps ($\Delta x$ and $\Delta t$) are varied independently.
Andrew B. Feldman, Gerhardt M., Ito H., Madore B. F., Mikhailov A. S., Mollison D., Richard J. Cohen, Rogers J. M., Tyson J. J., Weimar J. R., Yuri B. Chernyak, Zykov V. S.   +11 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Sub-Pixel Displacement Measurement with Swin Transformer: A Three-Level Classification Approach

Applied Sciences
In order to avoid the dependence of traditional sub-pixel displacement methods on interpolation method calculation, image gradient calculation, initial value estimation and iterative calculation, a Swin Transformer-based sub-pixel displacement ...
Yongxing Lin, Xiaoyan Xu, Zhixin Tie
doaj   +1 more source

Max 2-SAT with up to 108 qubits

New Journal of Physics, 2014
We experimentally study the performance of a programmable quantum annealing processor, the D-Wave One (DW1) with up to 108 qubits, on maximum SAT problem with 2 variables per clause (MAX 2-SAT) problems.
Siddhartha Santra, Gregory Quiroz, Greg Ver Steeg, Daniel A Lidar   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Exchange of Goods While Investing Into Production and Safety

Operations Research and Decisions, 2013
The tradeoff between production and safety investment is scrutinized for two agents who convert resources into production and safety investment while simultaneously exchanging goods voluntarily.
Kjell Hausken
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linear perturbations in viable f(R) theories

, 2013
We describe the cosmological evolution predicted by three distinct $f(R)$ theories, with emphasis on the evolution of linear perturbations. The most promising observational tools for distinguishing $f(R)$ theories from $\Lambda$CDM are those ...
Liddle, Andrew R., Lima, Nelson A.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source